STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMURF2E3 ubiquitin-protein ligase. (747 aa)    
Predicted Functional Partners:
SMAD7
Mothers against decapentaplegic homolog.
    
 0.999
SMAD6
MH2 domain-containing protein.
    
 0.996
SMAD2
Mothers against decapentaplegic homolog.
   
 0.996
TGFBR1
Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.
    
 0.996
SMURF1
E3 ubiquitin-protein ligase.
  
0.978
PTCH1
Patched 1.
    
 0.977
SMAD3
SMAD family member 3.
    
 0.977
PTCH2
Patched 2.
    
 0.964
SMAD4
Mothers against decapentaplegic homolog.
   
 0.935
USP15
Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.
    
 0.909
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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