STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SIM2SIM bHLH transcription factor 2. (611 aa)    
Predicted Functional Partners:
ARNT
Aryl hydrocarbon receptor nuclear translocator; Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and funct [...]
    
 
0.864
ARNT2
Aryl hydrocarbon receptor nuclear translocator 2.
    
 
0.764
SUMO1
Small ubiquitin-related modifier.
      
 0.744
SUMO2
Small ubiquitin-related modifier.
      
 0.743
G1SQP5_RABIT
Small ubiquitin-related modifier.
      
 0.574
G1TG12_RABIT
Small ubiquitin-related modifier.
      
 0.567
G1TM59_RABIT
Small ubiquitin-related modifier.
      
 0.567
G1TU65_RABIT
Small ubiquitin-related modifier.
      
 0.567
ENSOCUP00000041916
Small ubiquitin-related modifier.
      
 0.567
SLC13A1
Solute carrier family 13 member 1.
   
  
 0.436
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.