STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RHOARas homolog family member A. (193 aa)    
Predicted Functional Partners:
ROCK1
Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity (By similarity). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (By similarity). Phosphorylates FHOD1 and acts synergistically with it to promote SRC- dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 [...]
   
 0.999
ARHGDIB
Rho GDP dissociation inhibitor beta.
   
 0.996
ARHGAP35
Rho GTPase activating protein 35.
    
 0.994
ARHGEF11
Rho guanine nucleotide exchange factor 11.
   
 0.994
ARHGEF12
Rho guanine nucleotide exchange factor 12.
   
 0.994
ITSN2
Intersectin 2.
   
 0.993
ARHGEF2
Rho/Rac guanine nucleotide exchange factor 2.
   
 0.992
AKAP13
Uncharacterized protein.
   
 0.992
DAAM1
Dishevelled associated activator of morphogenesis 1.
    
 0.991
DIAPH1
DAD domain-containing protein.
   
 0.988
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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