STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PPP1R42Protein phosphatase 1 regulatory subunit 42. (310 aa)    
Predicted Functional Partners:
COPS2
COP9 signalosome subunit 2.
   
 0.969
COPS6
COP9 signalosome subunit 6.
   
 0.968
COPS4
COP9 signalosome subunit 4.
   
 0.966
COPS3
COP9 signalosome subunit 3.
   
 0.964
UBXN7
UBX domain-containing protein.
   
 0.944
NEDD8
NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity).
   
 0.943
COPS8
PCI domain-containing protein.
   
 0.907
ENSOCUP00000041941
CSN8_PSD8_EIF3K domain-containing protein.
   
 0.907
CUL2
Cullin 2; Belongs to the cullin family.
   
 0.890
DDB1
Damage specific DNA binding protein 1.
    
 0.885
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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