node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACO1 | FTH1 | ENSOCUP00000042092 | ENSOCUP00000012121 | Cytoplasmic aconitate hydratase; Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding; Belongs to the aconitase/IPM isomerase family. | Ferritin heavy chain; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). | 0.736 |
ACO1 | FTL | ENSOCUP00000042092 | ENSOCUP00000016423 | Cytoplasmic aconitate hydratase; Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding; Belongs to the aconitase/IPM isomerase family. | Ferritin light chain; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity); Belongs to the ferritin family. | 0.736 |
ACO1 | HAMP | ENSOCUP00000042092 | ENSOCUP00000024006 | Cytoplasmic aconitate hydratase; Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding; Belongs to the aconitase/IPM isomerase family. | Hepcidin antimicrobial peptide. | 0.744 |
ACO1 | IREB2 | ENSOCUP00000042092 | ENSOCUP00000008534 | Cytoplasmic aconitate hydratase; Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding; Belongs to the aconitase/IPM isomerase family. | Iron responsive element binding protein 2; Belongs to the aconitase/IPM isomerase family. | 0.525 |
ACO1 | SLC11A2 | ENSOCUP00000042092 | ENSOCUP00000006709 | Cytoplasmic aconitate hydratase; Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding; Belongs to the aconitase/IPM isomerase family. | Solute carrier family 11 member 2. | 0.708 |
ACO1 | SLC40A1 | ENSOCUP00000042092 | ENSOCUP00000004176 | Cytoplasmic aconitate hydratase; Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding; Belongs to the aconitase/IPM isomerase family. | Solute carrier family 40 member 1. | 0.631 |
ACO1 | TFRC | ENSOCUP00000042092 | ENSOCUP00000014641 | Cytoplasmic aconitate hydratase; Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding; Belongs to the aconitase/IPM isomerase family. | Transferrin receptor. | 0.821 |
ACSL4 | FTH1 | ENSOCUP00000034712 | ENSOCUP00000012121 | Acyl-CoA synthetase long chain family member 4. | Ferritin heavy chain; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). | 0.731 |
ACSL4 | FTL | ENSOCUP00000034712 | ENSOCUP00000016423 | Acyl-CoA synthetase long chain family member 4. | Ferritin light chain; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity); Belongs to the ferritin family. | 0.542 |
ACSL4 | IREB2 | ENSOCUP00000034712 | ENSOCUP00000008534 | Acyl-CoA synthetase long chain family member 4. | Iron responsive element binding protein 2; Belongs to the aconitase/IPM isomerase family. | 0.643 |
ACSL4 | NCOA4 | ENSOCUP00000034712 | ENSOCUP00000044898 | Acyl-CoA synthetase long chain family member 4. | Uncharacterized protein. | 0.546 |
ACSL4 | TFRC | ENSOCUP00000034712 | ENSOCUP00000014641 | Acyl-CoA synthetase long chain family member 4. | Transferrin receptor. | 0.698 |
FTH1 | ACO1 | ENSOCUP00000012121 | ENSOCUP00000042092 | Ferritin heavy chain; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). | Cytoplasmic aconitate hydratase; Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding; Belongs to the aconitase/IPM isomerase family. | 0.736 |
FTH1 | ACSL4 | ENSOCUP00000012121 | ENSOCUP00000034712 | Ferritin heavy chain; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). | Acyl-CoA synthetase long chain family member 4. | 0.731 |
FTH1 | FTL | ENSOCUP00000012121 | ENSOCUP00000016423 | Ferritin heavy chain; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). | Ferritin light chain; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity); Belongs to the ferritin family. | 0.996 |
FTH1 | G1U8Z6_RABIT | ENSOCUP00000012121 | ENSOCUP00000025914 | Ferritin heavy chain; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). | ARA70 domain-containing protein. | 0.976 |
FTH1 | HAMP | ENSOCUP00000012121 | ENSOCUP00000024006 | Ferritin heavy chain; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). | Hepcidin antimicrobial peptide. | 0.726 |
FTH1 | IREB2 | ENSOCUP00000012121 | ENSOCUP00000008534 | Ferritin heavy chain; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). | Iron responsive element binding protein 2; Belongs to the aconitase/IPM isomerase family. | 0.693 |
FTH1 | NCOA4 | ENSOCUP00000012121 | ENSOCUP00000044898 | Ferritin heavy chain; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). | Uncharacterized protein. | 0.978 |
FTH1 | SLC11A2 | ENSOCUP00000012121 | ENSOCUP00000006709 | Ferritin heavy chain; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). | Solute carrier family 11 member 2. | 0.702 |