node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTC1 | MYBPC3 | ENSOCUP00000006542 | ENSOCUP00000001825 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Myosin binding protein C, cardiac. | 0.805 |
ACTC1 | MYH11 | ENSOCUP00000006542 | ENSOCUP00000024188 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Myosin-11; Muscle contraction. | 0.686 |
ACTC1 | MYH7 | ENSOCUP00000006542 | ENSOCUP00000021291 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Myosin-7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.887 |
ACTC1 | MYL1 | ENSOCUP00000006542 | ENSOCUP00000038248 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Myosin light chain 1/3, skeletal muscle isoform; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. | 0.940 |
ACTC1 | MYL2 | ENSOCUP00000006542 | ENSOCUP00000028408 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...] | 0.979 |
ACTC1 | MYL3 | ENSOCUP00000006542 | ENSOCUP00000029317 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Myosin light chain 3. | 0.771 |
ACTC1 | TNNI1 | ENSOCUP00000006542 | ENSOCUP00000008977 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Troponin I, slow skeletal muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.732 |
ACTC1 | TNNT2 | ENSOCUP00000006542 | ENSOCUP00000018870 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Troponin T, cardiac muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.986 |
ACTC1 | TNNT3 | ENSOCUP00000006542 | ENSOCUP00000001509 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Troponin T, fast skeletal muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.795 |
ACTC1 | TPM1 | ENSOCUP00000006542 | ENSOCUP00000012137 | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | Tropomyosin alpha-1 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments; Belongs to the tropomyosin family. | 0.988 |
MYBPC3 | ACTC1 | ENSOCUP00000001825 | ENSOCUP00000006542 | Myosin binding protein C, cardiac. | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | 0.805 |
MYBPC3 | MYH7 | ENSOCUP00000001825 | ENSOCUP00000021291 | Myosin binding protein C, cardiac. | Myosin-7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.902 |
MYBPC3 | MYL1 | ENSOCUP00000001825 | ENSOCUP00000038248 | Myosin binding protein C, cardiac. | Myosin light chain 1/3, skeletal muscle isoform; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. | 0.670 |
MYBPC3 | MYL2 | ENSOCUP00000001825 | ENSOCUP00000028408 | Myosin binding protein C, cardiac. | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin [...] | 0.864 |
MYBPC3 | MYL3 | ENSOCUP00000001825 | ENSOCUP00000029317 | Myosin binding protein C, cardiac. | Myosin light chain 3. | 0.890 |
MYBPC3 | TNNI1 | ENSOCUP00000001825 | ENSOCUP00000008977 | Myosin binding protein C, cardiac. | Troponin I, slow skeletal muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.618 |
MYBPC3 | TNNT2 | ENSOCUP00000001825 | ENSOCUP00000018870 | Myosin binding protein C, cardiac. | Troponin T, cardiac muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.919 |
MYBPC3 | TNNT3 | ENSOCUP00000001825 | ENSOCUP00000001509 | Myosin binding protein C, cardiac. | Troponin T, fast skeletal muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | 0.509 |
MYBPC3 | TPM1 | ENSOCUP00000001825 | ENSOCUP00000012137 | Myosin binding protein C, cardiac. | Tropomyosin alpha-1 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments; Belongs to the tropomyosin family. | 0.819 |
MYH11 | ACTC1 | ENSOCUP00000024188 | ENSOCUP00000006542 | Myosin-11; Muscle contraction. | Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | 0.686 |