MAPKAPK2 protein (Oryctolagus cuniculus) - STRING interaction network

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MAPKAPK2

MAP kinase-activated protein kinase 2; Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT1 [...] (379 aa)

Predicted Functional Partners:

HSPB1

0.998

MAPK12

0.993

MAPK13

0.993

ZFP36

0.987

MAPKAPK3

0.982

ZFP36L2

0.962

MAP2K6

0.960

ZFP36L1

0.960

HSPB6

0.789

MAPK3

0.775

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HSPB1	HSPB6	ENSOCUP00000010917	ENSOCUP00000023191	Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family.	Heat shock protein family B (small) member 6; Belongs to the small heat shock protein (HSP20) family.	0.514
HSPB1	MAPK12	ENSOCUP00000010917	ENSOCUP00000034260	Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family.	Mitogen-activated protein kinase.	0.538
HSPB1	MAPK13	ENSOCUP00000010917	ENSOCUP00000047230	Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family.	Mitogen-activated protein kinase.	0.538
HSPB1	MAPKAPK2	ENSOCUP00000010917	ENSOCUP00000012250	Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family.	MAP kinase-activated protein kinase 2; Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT1 [...]	0.998
HSPB1	MAPKAPK3	ENSOCUP00000010917	ENSOCUP00000004611	Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family.	MAPK activated protein kinase 3; Belongs to the protein kinase superfamily.	0.991
HSPB6	HSPB1	ENSOCUP00000023191	ENSOCUP00000010917	Heat shock protein family B (small) member 6; Belongs to the small heat shock protein (HSP20) family.	Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family.	0.514
HSPB6	MAPKAPK2	ENSOCUP00000023191	ENSOCUP00000012250	Heat shock protein family B (small) member 6; Belongs to the small heat shock protein (HSP20) family.	MAP kinase-activated protein kinase 2; Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT1 [...]	0.789
HSPB6	MAPKAPK3	ENSOCUP00000023191	ENSOCUP00000004611	Heat shock protein family B (small) member 6; Belongs to the small heat shock protein (HSP20) family.	MAPK activated protein kinase 3; Belongs to the protein kinase superfamily.	0.742
MAP2K6	MAPK12	ENSOCUP00000006577	ENSOCUP00000034260	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.988
MAP2K6	MAPK13	ENSOCUP00000006577	ENSOCUP00000047230	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.988
MAP2K6	MAPK3	ENSOCUP00000006577	ENSOCUP00000011800	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.973
MAP2K6	MAPKAPK2	ENSOCUP00000006577	ENSOCUP00000012250	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	MAP kinase-activated protein kinase 2; Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT1 [...]	0.960
MAP2K6	MAPKAPK3	ENSOCUP00000006577	ENSOCUP00000004611	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	MAPK activated protein kinase 3; Belongs to the protein kinase superfamily.	0.608
MAPK12	HSPB1	ENSOCUP00000034260	ENSOCUP00000010917	Mitogen-activated protein kinase.	Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family.	0.538
MAPK12	MAP2K6	ENSOCUP00000034260	ENSOCUP00000006577	Mitogen-activated protein kinase.	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.	0.988
MAPK12	MAPK13	ENSOCUP00000034260	ENSOCUP00000047230	Mitogen-activated protein kinase.	Mitogen-activated protein kinase.	0.964
MAPK12	MAPK3	ENSOCUP00000034260	ENSOCUP00000011800	Mitogen-activated protein kinase.	Mitogen-activated protein kinase.	0.945
MAPK12	MAPKAPK2	ENSOCUP00000034260	ENSOCUP00000012250	Mitogen-activated protein kinase.	MAP kinase-activated protein kinase 2; Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT1 [...]	0.993
MAPK12	MAPKAPK3	ENSOCUP00000034260	ENSOCUP00000004611	Mitogen-activated protein kinase.	MAPK activated protein kinase 3; Belongs to the protein kinase superfamily.	0.989
MAPK13	HSPB1	ENSOCUP00000047230	ENSOCUP00000010917	Mitogen-activated protein kinase.	Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family.	0.538

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