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PIGR protein (Oryctolagus cuniculus) - STRING interaction network
"PIGR" - Polymeric immunoglobulin receptor in Oryctolagus cuniculus
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
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[Homology]
Score
PIGRPolymeric immunoglobulin receptor; This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment (771 aa)    
Predicted Functional Partners:
IGJ
Immunoglobulin J chain; Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component (158 aa)
     
   
  0.918
PIGA
Phosphatidylinositol glycan anchor biosynthesis, class A (485 aa)
     
   
  0.908
MIS12
MIS12 kinetochore complex component (187 aa)
       
      0.814
FCRN
Uncharacterized protein; Neonatal Fc receptor alpha chain ; Belongs to the MHC class I family (359 aa)
     
   
  0.733
PTAFR
Platelet-activating factor receptor; Belongs to the G-protein coupled receptor 1 family (342 aa)
     
   
  0.638
RAB3B
RAB3B, member RAS oncogene family (219 aa)
       
 
  0.636
PIGM
Phosphatidylinositol glycan anchor biosynthesis, class M (423 aa)
           
  0.634
C3
Complement C3 alpha chain; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates (1114 aa)
     
   
  0.631
FCRLA
Fc receptor-like A (342 aa)
           
  0.630
FRK
Fyn-related Src family tyrosine kinase (354 aa)
     
        0.609
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, Oryctolagus cuniculus, domestic rabbit, rabbit, rabbits
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