SPEG protein (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CUL7	PES1	ENSOCUP00000001360	ENSOCUP00000008324	Cullin 7; Belongs to the cullin family.	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family.	0.579
CUL7	SPEG	ENSOCUP00000001360	ENSOCUP00000012415	Cullin 7; Belongs to the cullin family.	Ig-like domain-containing protein.	0.677
CUL7	TEX10	ENSOCUP00000001360	ENSOCUP00000003672	Cullin 7; Belongs to the cullin family.	Testis expressed 10.	0.578
DAPK2	SPEG	ENSOCUP00000042075	ENSOCUP00000012415	Death associated protein kinase 2; Belongs to the protein kinase superfamily.	Ig-like domain-containing protein.	0.603
MTM1	RYR1	ENSOCUP00000033110	ENSOCUP00000025335	Myotubularin 1.	Ryanodine receptor 1; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high- level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (By similarity). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. [...]	0.753
MTM1	SPEG	ENSOCUP00000033110	ENSOCUP00000012415	Myotubularin 1.	Ig-like domain-containing protein.	0.735
PES1	CUL7	ENSOCUP00000008324	ENSOCUP00000001360	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family.	Cullin 7; Belongs to the cullin family.	0.579
PES1	SPEG	ENSOCUP00000008324	ENSOCUP00000012415	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family.	Ig-like domain-containing protein.	0.653
PES1	TEX10	ENSOCUP00000008324	ENSOCUP00000003672	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family.	Testis expressed 10.	0.969
PRMT1	SPEG	ENSOCUP00000023989	ENSOCUP00000012415	Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Ig-like domain-containing protein.	0.604
RYR1	MTM1	ENSOCUP00000025335	ENSOCUP00000033110	Ryanodine receptor 1; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high- level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (By similarity). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. [...]	Myotubularin 1.	0.753
RYR1	SPEG	ENSOCUP00000025335	ENSOCUP00000012415	Ryanodine receptor 1; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high- level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (By similarity). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. [...]	Ig-like domain-containing protein.	0.605
SPEG	CUL7	ENSOCUP00000012415	ENSOCUP00000001360	Ig-like domain-containing protein.	Cullin 7; Belongs to the cullin family.	0.677
SPEG	DAPK2	ENSOCUP00000012415	ENSOCUP00000042075	Ig-like domain-containing protein.	Death associated protein kinase 2; Belongs to the protein kinase superfamily.	0.603
SPEG	MTM1	ENSOCUP00000012415	ENSOCUP00000033110	Ig-like domain-containing protein.	Myotubularin 1.	0.735
SPEG	PES1	ENSOCUP00000012415	ENSOCUP00000008324	Ig-like domain-containing protein.	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family.	0.653
SPEG	PRMT1	ENSOCUP00000012415	ENSOCUP00000023989	Ig-like domain-containing protein.	Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	0.604
SPEG	RYR1	ENSOCUP00000012415	ENSOCUP00000025335	Ig-like domain-containing protein.	Ryanodine receptor 1; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high- level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (By similarity). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. [...]	0.605
SPEG	TCAP	ENSOCUP00000012415	ENSOCUP00000021853	Ig-like domain-containing protein.	Titin-cap.	0.612
SPEG	TEX10	ENSOCUP00000012415	ENSOCUP00000003672	Ig-like domain-containing protein.	Testis expressed 10.	0.599