node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ESR1 | FKBP4 | ENSOCUP00000004174 | ENSOCUP00000048194 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed; Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May [...] | 0.714 |
ESR1 | G1TJP7_RABIT | ENSOCUP00000004174 | ENSOCUP00000017176 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | SANT domain-containing protein. | 0.882 |
ESR1 | NCOA1 | ENSOCUP00000004174 | ENSOCUP00000013252 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Nuclear receptor coactivator. | 0.999 |
ESR1 | NCOA3 | ENSOCUP00000004174 | ENSOCUP00000037443 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Nuclear receptor coactivator. | 0.999 |
ESR1 | NCOR1 | ENSOCUP00000004174 | ENSOCUP00000009022 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Nuclear receptor corepressor 1. | 0.992 |
ESR1 | PGR | ENSOCUP00000004174 | ENSOCUP00000012634 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation; Belongs to the nuclear hormone receptor family. NR3 subfamily. | 0.963 |
ESR1 | PIK3CA | ENSOCUP00000004174 | ENSOCUP00000026298 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.882 |
ESR1 | PIK3CB | ENSOCUP00000004174 | ENSOCUP00000004241 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. | 0.456 |
ESR1 | PIK3R1 | ENSOCUP00000004174 | ENSOCUP00000004433 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Phosphoinositide-3-kinase regulatory subunit 1. | 0.876 |
ESR1 | PRKACB | ENSOCUP00000004174 | ENSOCUP00000043583 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. | 0.957 |
FKBP4 | ESR1 | ENSOCUP00000048194 | ENSOCUP00000004174 | Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed; Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May [...] | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.714 |
FKBP4 | PGR | ENSOCUP00000048194 | ENSOCUP00000012634 | Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed; Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May [...] | Progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation; Belongs to the nuclear hormone receptor family. NR3 subfamily. | 0.935 |
G1TJP7_RABIT | ESR1 | ENSOCUP00000017176 | ENSOCUP00000004174 | SANT domain-containing protein. | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.882 |
G1TJP7_RABIT | NCOA1 | ENSOCUP00000017176 | ENSOCUP00000013252 | SANT domain-containing protein. | Nuclear receptor coactivator. | 0.575 |
G1TJP7_RABIT | NCOA3 | ENSOCUP00000017176 | ENSOCUP00000037443 | SANT domain-containing protein. | Nuclear receptor coactivator. | 0.588 |
G1TJP7_RABIT | NCOR1 | ENSOCUP00000017176 | ENSOCUP00000009022 | SANT domain-containing protein. | Nuclear receptor corepressor 1. | 0.902 |
G1TJP7_RABIT | PGR | ENSOCUP00000017176 | ENSOCUP00000012634 | SANT domain-containing protein. | Progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation; Belongs to the nuclear hormone receptor family. NR3 subfamily. | 0.933 |
NCOA1 | ESR1 | ENSOCUP00000013252 | ENSOCUP00000004174 | Nuclear receptor coactivator. | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.999 |
NCOA1 | G1TJP7_RABIT | ENSOCUP00000013252 | ENSOCUP00000017176 | Nuclear receptor coactivator. | SANT domain-containing protein. | 0.575 |
NCOA1 | NCOA3 | ENSOCUP00000013252 | ENSOCUP00000037443 | Nuclear receptor coactivator. | Nuclear receptor coactivator. | 0.983 |