SEMA4B protein (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SEMA4B

Semaphorin 4B; Belongs to the semaphorin family. (832 aa)

Predicted Functional Partners:

PLXNB1

0.963

PLXNA1

0.730

DCBLD2

0.661

MET

0.660

MST1R

0.660

PLXND1

0.610

PLXNA4

0.604

PLXNA2

0.597

PLXNB3

0.568

PLXNA3

0.565

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DCBLD2	SEMA4B	ENSOCUP00000044350	ENSOCUP00000012823	Discoidin, CUB and LCCL domain containing 2.	Semaphorin 4B; Belongs to the semaphorin family.	0.661
MET	MST1R	ENSOCUP00000003111	ENSOCUP00000008078	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Macrophage stimulating 1 receptor.	0.715
MET	PLXNB1	ENSOCUP00000003111	ENSOCUP00000001660	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Plexin B1.	0.929
MET	SEMA4B	ENSOCUP00000003111	ENSOCUP00000012823	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	Semaphorin 4B; Belongs to the semaphorin family.	0.660
MST1R	MET	ENSOCUP00000008078	ENSOCUP00000003111	Macrophage stimulating 1 receptor.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.715
MST1R	PLXNA1	ENSOCUP00000008078	ENSOCUP00000003178	Macrophage stimulating 1 receptor.	Plexin A1.	0.483
MST1R	PLXNA2	ENSOCUP00000008078	ENSOCUP00000003028	Macrophage stimulating 1 receptor.	Plexin A2.	0.483
MST1R	PLXNA3	ENSOCUP00000008078	ENSOCUP00000041487	Macrophage stimulating 1 receptor.	Sema domain-containing protein.	0.483
MST1R	PLXNA4	ENSOCUP00000008078	ENSOCUP00000028707	Macrophage stimulating 1 receptor.	Plexin A4.	0.483
MST1R	PLXNB1	ENSOCUP00000008078	ENSOCUP00000001660	Macrophage stimulating 1 receptor.	Plexin B1.	0.718
MST1R	PLXNB3	ENSOCUP00000008078	ENSOCUP00000014201	Macrophage stimulating 1 receptor.	Plexin B3.	0.702
MST1R	PLXND1	ENSOCUP00000008078	ENSOCUP00000011241	Macrophage stimulating 1 receptor.	Plexin D1.	0.483
MST1R	SEMA4B	ENSOCUP00000008078	ENSOCUP00000012823	Macrophage stimulating 1 receptor.	Semaphorin 4B; Belongs to the semaphorin family.	0.660
PLXNA1	MST1R	ENSOCUP00000003178	ENSOCUP00000008078	Plexin A1.	Macrophage stimulating 1 receptor.	0.483
PLXNA1	PLXNA2	ENSOCUP00000003178	ENSOCUP00000003028	Plexin A1.	Plexin A2.	0.475
PLXNA1	PLXNA4	ENSOCUP00000003178	ENSOCUP00000028707	Plexin A1.	Plexin A4.	0.539
PLXNA1	PLXND1	ENSOCUP00000003178	ENSOCUP00000011241	Plexin A1.	Plexin D1.	0.565
PLXNA1	SEMA4B	ENSOCUP00000003178	ENSOCUP00000012823	Plexin A1.	Semaphorin 4B; Belongs to the semaphorin family.	0.730
PLXNA2	MST1R	ENSOCUP00000003028	ENSOCUP00000008078	Plexin A2.	Macrophage stimulating 1 receptor.	0.483
PLXNA2	PLXNA1	ENSOCUP00000003028	ENSOCUP00000003178	Plexin A2.	Plexin A1.	0.475