THOC3 protein (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

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Textmining

[Homology]

Score

THOC3

THO complex 3. (351 aa)

Predicted Functional Partners:

THOC1

0.999

THOC2

0.999

THOC5

0.999

THOC7

0.998

DDX39B

0.989

G1SWM0_RABIT

0.974

ENSOCUP00000045788

0.956

ZC3H13

0.951

SARNP

0.934

POLDIP3

0.932

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDX39B	ENSOCUP00000045788	ENSOCUP00000025395	ENSOCUP00000045788	DExD-box helicase 39B.	Uncharacterized protein.	0.826
DDX39B	G1SWM0_RABIT	ENSOCUP00000025395	ENSOCUP00000007888	DExD-box helicase 39B.	Uncharacterized protein.	0.937
DDX39B	POLDIP3	ENSOCUP00000025395	ENSOCUP00000013861	DExD-box helicase 39B.	DNA polymerase delta interacting protein 3.	0.981
DDX39B	SARNP	ENSOCUP00000025395	ENSOCUP00000008719	DExD-box helicase 39B.	SAP domain containing ribonucleoprotein.	0.994
DDX39B	THOC1	ENSOCUP00000025395	ENSOCUP00000009981	DExD-box helicase 39B.	THO complex 1.	0.990
DDX39B	THOC2	ENSOCUP00000025395	ENSOCUP00000030129	DExD-box helicase 39B.	THO complex 2.	0.991
DDX39B	THOC3	ENSOCUP00000025395	ENSOCUP00000014080	DExD-box helicase 39B.	THO complex 3.	0.989
DDX39B	THOC5	ENSOCUP00000025395	ENSOCUP00000031661	DExD-box helicase 39B.	THO complex 5.	0.966
DDX39B	THOC7	ENSOCUP00000025395	ENSOCUP00000015570	DExD-box helicase 39B.	THO complex 7.	0.958
DDX39B	ZC3H13	ENSOCUP00000025395	ENSOCUP00000020895	DExD-box helicase 39B.	Zinc finger CCCH-type containing 13.	0.877
ENSOCUP00000045788	DDX39B	ENSOCUP00000045788	ENSOCUP00000025395	Uncharacterized protein.	DExD-box helicase 39B.	0.826
ENSOCUP00000045788	G1SWM0_RABIT	ENSOCUP00000045788	ENSOCUP00000007888	Uncharacterized protein.	Uncharacterized protein.	0.896
ENSOCUP00000045788	POLDIP3	ENSOCUP00000045788	ENSOCUP00000013861	Uncharacterized protein.	DNA polymerase delta interacting protein 3.	0.847
ENSOCUP00000045788	SARNP	ENSOCUP00000045788	ENSOCUP00000008719	Uncharacterized protein.	SAP domain containing ribonucleoprotein.	0.814
ENSOCUP00000045788	THOC2	ENSOCUP00000045788	ENSOCUP00000030129	Uncharacterized protein.	THO complex 2.	0.880
ENSOCUP00000045788	THOC3	ENSOCUP00000045788	ENSOCUP00000014080	Uncharacterized protein.	THO complex 3.	0.956
ENSOCUP00000045788	THOC5	ENSOCUP00000045788	ENSOCUP00000031661	Uncharacterized protein.	THO complex 5.	0.962
ENSOCUP00000045788	THOC7	ENSOCUP00000045788	ENSOCUP00000015570	Uncharacterized protein.	THO complex 7.	0.896
ENSOCUP00000045788	ZC3H13	ENSOCUP00000045788	ENSOCUP00000020895	Uncharacterized protein.	Zinc finger CCCH-type containing 13.	0.880
G1SWM0_RABIT	DDX39B	ENSOCUP00000007888	ENSOCUP00000025395	Uncharacterized protein.	DExD-box helicase 39B.	0.937

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

27

PPI enrichment p-value:

1.05e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

11 of 104

1.5

3.1

6.57e-14

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019843

rRNA binding

10 of 40

1.87

5.09

5.87e-16

GO:0003735

Structural constituent of ribosome

11 of 51

1.81

5.01

2.68e-17

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

11 of 57

1.76

4.78

1.76e-17

GO:0044391

Ribosomal subunit

4 of 12

2.0

2.62

2.79e-06

GO:0015934

Large ribosomal subunit

3 of 6

2.17

2.24

4.01e-05

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:34833134

(2021) Genome-Wide Investigation and Analysis of Microsatellites and Compound Microsatellites in Leptolyngbya-like Species, Cyanobacteria.

6 of 15

2.08

4.05

8.68e-10

PMID:32977771

(2020) Role of diversity-generating retroelements for regulatory pathway tuning in cyanobacteria.

2 of 2

2.47

1.47

0.0019

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:151

rRNA-binding

10 of 13

2.36

8.32

1.13e-19

CL:149

rRNA-binding

11 of 21

2.19

7.89

7.79e-21

CL:152

Mixed, incl. Large ribosomal subunit, and K Homology domain, type 2

6 of 7

2.41

5.29

1.63e-11

CL:165

KOW (Kyprides, Ouzounis, Woese) motif., and rRNA-binding

4 of 6

2.3

3.19

4.89e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

cgc03010

Ribosome

11 of 53

1.79

5.02

6.52e-18

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005840

Ribosome

8 of 39

1.79

3.73

3.88e-11

GOCC:0044391

Ribosomal subunit

6 of 19

1.97

3.67

2.96e-09

GOCC:0022626

Cytosolic ribosome

4 of 16

1.87

2.28

1.04e-05

GOCC:0015934

Large ribosomal subunit

3 of 6

2.17

2.13

6.70e-05

GOCC:0022627

Cytosolic small ribosomal subunit

3 of 13

1.84

1.65

0.00036

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0699

rRNA-binding

10 of 39

1.88

5.26

1.55e-16

KW-0689

Ribosomal protein

11 of 57

1.76

4.76

2.68e-17

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