| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCKBR | GNAO1 | ENSOCUP00000006740 | ENSOCUP00000040227 | Gastrin/cholecystokinin type B receptor; Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | G protein subunit alpha o1. | 0.431 |
| CCKBR | GNAQ | ENSOCUP00000006740 | ENSOCUP00000014234 | Gastrin/cholecystokinin type B receptor; Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | G protein subunit alpha q. | 0.917 |
| CCKBR | GNB1 | ENSOCUP00000006740 | ENSOCUP00000008676 | Gastrin/cholecystokinin type B receptor; Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | G protein subunit beta 1. | 0.867 |
| CCKBR | GNB3 | ENSOCUP00000006740 | ENSOCUP00000011129 | Gastrin/cholecystokinin type B receptor; Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | G protein subunit beta 3. | 0.896 |
| CCKBR | GNB4 | ENSOCUP00000006740 | ENSOCUP00000000803 | Gastrin/cholecystokinin type B receptor; Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | G protein subunit beta 4. | 0.867 |
| CCKBR | GNB5 | ENSOCUP00000006740 | ENSOCUP00000010220 | Gastrin/cholecystokinin type B receptor; Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, incl [...] | 0.888 |
| CYSLTR2 | GNAQ | ENSOCUP00000018900 | ENSOCUP00000014234 | G_PROTEIN_RECEP_F1_2 domain-containing protein. | G protein subunit alpha q. | 0.915 |
| CYSLTR2 | PLCB4 | ENSOCUP00000018900 | ENSOCUP00000044905 | G_PROTEIN_RECEP_F1_2 domain-containing protein. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. | 0.800 |
| GNAO1 | CCKBR | ENSOCUP00000040227 | ENSOCUP00000006740 | G protein subunit alpha o1. | Gastrin/cholecystokinin type B receptor; Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | 0.431 |
| GNAO1 | GNAQ | ENSOCUP00000040227 | ENSOCUP00000014234 | G protein subunit alpha o1. | G protein subunit alpha q. | 0.921 |
| GNAO1 | GNB1 | ENSOCUP00000040227 | ENSOCUP00000008676 | G protein subunit alpha o1. | G protein subunit beta 1. | 0.970 |
| GNAO1 | GNB3 | ENSOCUP00000040227 | ENSOCUP00000011129 | G protein subunit alpha o1. | G protein subunit beta 3. | 0.972 |
| GNAO1 | GNB4 | ENSOCUP00000040227 | ENSOCUP00000000803 | G protein subunit alpha o1. | G protein subunit beta 4. | 0.974 |
| GNAO1 | GNB5 | ENSOCUP00000040227 | ENSOCUP00000010220 | G protein subunit alpha o1. | Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, incl [...] | 0.951 |
| GNAO1 | NRAS | ENSOCUP00000040227 | ENSOCUP00000019559 | G protein subunit alpha o1. | NRAS proto-oncogene, GTPase. | 0.477 |
| GNAO1 | PLCB1 | ENSOCUP00000040227 | ENSOCUP00000036536 | G protein subunit alpha o1. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. | 0.905 |
| GNAO1 | PLCB4 | ENSOCUP00000040227 | ENSOCUP00000044905 | G protein subunit alpha o1. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. | 0.892 |
| GNAQ | CCKBR | ENSOCUP00000014234 | ENSOCUP00000006740 | G protein subunit alpha q. | Gastrin/cholecystokinin type B receptor; Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | 0.917 |
| GNAQ | CYSLTR2 | ENSOCUP00000014234 | ENSOCUP00000018900 | G protein subunit alpha q. | G_PROTEIN_RECEP_F1_2 domain-containing protein. | 0.915 |
| GNAQ | GNAO1 | ENSOCUP00000014234 | ENSOCUP00000040227 | G protein subunit alpha q. | G protein subunit alpha o1. | 0.921 |
