node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHRM2 | GNAI1 | ENSOCUP00000014240 | ENSOCUP00000000882 | Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. | G protein subunit alpha i1. | 0.922 |
CHRM2 | GNAI2 | ENSOCUP00000014240 | ENSOCUP00000019624 | Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. | G protein subunit alpha i2. | 0.928 |
CHRM2 | GNAI3 | ENSOCUP00000014240 | ENSOCUP00000004821 | Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. | G protein subunit alpha i3. | 0.922 |
CHRM2 | GNB1 | ENSOCUP00000014240 | ENSOCUP00000008676 | Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. | G protein subunit beta 1. | 0.938 |
CHRM2 | GNB2 | ENSOCUP00000014240 | ENSOCUP00000042929 | Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. | G protein subunit beta 2. | 0.937 |
CHRM2 | GNB3 | ENSOCUP00000014240 | ENSOCUP00000011129 | Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. | G protein subunit beta 3. | 0.924 |
CHRM2 | GNB4 | ENSOCUP00000014240 | ENSOCUP00000000803 | Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. | G protein subunit beta 4. | 0.938 |
CHRM2 | GNB5 | ENSOCUP00000014240 | ENSOCUP00000010220 | Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. | Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, incl [...] | 0.940 |
CHRM2 | GNG12 | ENSOCUP00000014240 | ENSOCUP00000020657 | Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.926 |
CHRM2 | GNG4 | ENSOCUP00000014240 | ENSOCUP00000005907 | Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.934 |
GNAI1 | CHRM2 | ENSOCUP00000000882 | ENSOCUP00000014240 | G protein subunit alpha i1. | Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. | 0.922 |
GNAI1 | GNAI2 | ENSOCUP00000000882 | ENSOCUP00000019624 | G protein subunit alpha i1. | G protein subunit alpha i2. | 0.973 |
GNAI1 | GNAI3 | ENSOCUP00000000882 | ENSOCUP00000004821 | G protein subunit alpha i1. | G protein subunit alpha i3. | 0.902 |
GNAI1 | GNB1 | ENSOCUP00000000882 | ENSOCUP00000008676 | G protein subunit alpha i1. | G protein subunit beta 1. | 0.978 |
GNAI1 | GNB2 | ENSOCUP00000000882 | ENSOCUP00000042929 | G protein subunit alpha i1. | G protein subunit beta 2. | 0.944 |
GNAI1 | GNB3 | ENSOCUP00000000882 | ENSOCUP00000011129 | G protein subunit alpha i1. | G protein subunit beta 3. | 0.933 |
GNAI1 | GNB4 | ENSOCUP00000000882 | ENSOCUP00000000803 | G protein subunit alpha i1. | G protein subunit beta 4. | 0.962 |
GNAI1 | GNB5 | ENSOCUP00000000882 | ENSOCUP00000010220 | G protein subunit alpha i1. | Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, incl [...] | 0.920 |
GNAI1 | GNG12 | ENSOCUP00000000882 | ENSOCUP00000020657 | G protein subunit alpha i1. | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.867 |
GNAI1 | GNG4 | ENSOCUP00000000882 | ENSOCUP00000005907 | G protein subunit alpha i1. | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.900 |