node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGT | EDN1 | ENSOCUP00000000417 | ENSOCUP00000011526 | Angiotensinogen; Belongs to the serpin family. | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | 0.808 |
AGT | EDN2 | ENSOCUP00000000417 | ENSOCUP00000001041 | Angiotensinogen; Belongs to the serpin family. | Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family. | 0.417 |
AGT | EDN3 | ENSOCUP00000000417 | ENSOCUP00000046269 | Angiotensinogen; Belongs to the serpin family. | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family. | 0.492 |
AGT | EDNRA | ENSOCUP00000000417 | ENSOCUP00000001082 | Angiotensinogen; Belongs to the serpin family. | Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. | 0.975 |
AGT | EDNRB | ENSOCUP00000000417 | ENSOCUP00000015272 | Angiotensinogen; Belongs to the serpin family. | Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily. | 0.962 |
AGT | GNAQ | ENSOCUP00000000417 | ENSOCUP00000014234 | Angiotensinogen; Belongs to the serpin family. | G protein subunit alpha q. | 0.540 |
AGT | KNG1 | ENSOCUP00000000417 | ENSOCUP00000033073 | Angiotensinogen; Belongs to the serpin family. | Kininogen 1. | 0.772 |
EDN1 | AGT | ENSOCUP00000011526 | ENSOCUP00000000417 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | Angiotensinogen; Belongs to the serpin family. | 0.808 |
EDN1 | EDN2 | ENSOCUP00000011526 | ENSOCUP00000001041 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family. | 0.960 |
EDN1 | EDN3 | ENSOCUP00000011526 | ENSOCUP00000046269 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family. | 0.965 |
EDN1 | EDNRA | ENSOCUP00000011526 | ENSOCUP00000001082 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. | 0.999 |
EDN1 | EDNRB | ENSOCUP00000011526 | ENSOCUP00000015272 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily. | 0.999 |
EDN1 | GNAQ | ENSOCUP00000011526 | ENSOCUP00000014234 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | G protein subunit alpha q. | 0.456 |
EDN1 | KNG1 | ENSOCUP00000011526 | ENSOCUP00000033073 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | Kininogen 1. | 0.533 |
EDN2 | AGT | ENSOCUP00000001041 | ENSOCUP00000000417 | Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family. | Angiotensinogen; Belongs to the serpin family. | 0.417 |
EDN2 | EDN1 | ENSOCUP00000001041 | ENSOCUP00000011526 | Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family. | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | 0.960 |
EDN2 | EDN3 | ENSOCUP00000001041 | ENSOCUP00000046269 | Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family. | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family. | 0.962 |
EDN2 | EDNRA | ENSOCUP00000001041 | ENSOCUP00000001082 | Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family. | Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. | 0.992 |
EDN2 | EDNRB | ENSOCUP00000001041 | ENSOCUP00000015272 | Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family. | Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily. | 0.997 |
EDN3 | AGT | ENSOCUP00000046269 | ENSOCUP00000000417 | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family. | Angiotensinogen; Belongs to the serpin family. | 0.492 |