node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BST1 | CD38 | ENSOCUP00000002016 | ENSOCUP00000040603 | Bone marrow stromal cell antigen 1. | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. | 0.922 |
BST1 | NAMPT | ENSOCUP00000002016 | ENSOCUP00000011549 | Bone marrow stromal cell antigen 1. | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | 0.930 |
BST1 | NMNAT1 | ENSOCUP00000002016 | ENSOCUP00000019903 | Bone marrow stromal cell antigen 1. | Nicotinamide-nucleotide adenylyltransferase. | 0.927 |
BST1 | NMNAT2 | ENSOCUP00000002016 | ENSOCUP00000042827 | Bone marrow stromal cell antigen 1. | CTP_transf_like domain-containing protein. | 0.924 |
BST1 | PNP | ENSOCUP00000002016 | ENSOCUP00000004354 | Bone marrow stromal cell antigen 1. | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.913 |
BST1 | SIRT1 | ENSOCUP00000002016 | ENSOCUP00000022814 | Bone marrow stromal cell antigen 1. | Sirtuin 1. | 0.909 |
BST1 | SIRT3 | ENSOCUP00000002016 | ENSOCUP00000044429 | Bone marrow stromal cell antigen 1. | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. | 0.910 |
BST1 | SIRT5 | ENSOCUP00000002016 | ENSOCUP00000038921 | Bone marrow stromal cell antigen 1. | NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] | 0.912 |
CD38 | BST1 | ENSOCUP00000040603 | ENSOCUP00000002016 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. | Bone marrow stromal cell antigen 1. | 0.922 |
CD38 | NAMPT | ENSOCUP00000040603 | ENSOCUP00000011549 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | 0.961 |
CD38 | NMNAT1 | ENSOCUP00000040603 | ENSOCUP00000019903 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. | Nicotinamide-nucleotide adenylyltransferase. | 0.949 |
CD38 | NMNAT2 | ENSOCUP00000040603 | ENSOCUP00000042827 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. | CTP_transf_like domain-containing protein. | 0.936 |
CD38 | PNP | ENSOCUP00000040603 | ENSOCUP00000004354 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.920 |
CD38 | PRKCB | ENSOCUP00000040603 | ENSOCUP00000046202 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. | Protein kinase C beta type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR- induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser- [...] | 0.923 |
CD38 | RYR3 | ENSOCUP00000040603 | ENSOCUP00000045001 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. | Ryanodine receptor 3; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca(2+) release by other calcium channels. Calcium channel that mediates Ca(2+)-induced Ca(2+) release from the endoplasmic reticulum in non-muscle cells. Plays a role in cellular calcium signaling. Contributes to cellular calcium ion homeostasis. Isoform 2 lacks a predicted transmembrane segment and does not form functional calcium channels by itself; however, it can form tetramers [...] | 0.922 |
CD38 | SIRT1 | ENSOCUP00000040603 | ENSOCUP00000022814 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. | Sirtuin 1. | 0.946 |
CD38 | SIRT3 | ENSOCUP00000040603 | ENSOCUP00000044429 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. | 0.933 |
CD38 | SIRT5 | ENSOCUP00000040603 | ENSOCUP00000038921 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. | NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] | 0.917 |
NAMPT | BST1 | ENSOCUP00000011549 | ENSOCUP00000002016 | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | Bone marrow stromal cell antigen 1. | 0.930 |
NAMPT | CD38 | ENSOCUP00000011549 | ENSOCUP00000040603 | Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. | 0.961 |