node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AIFM1 | DAO | ENSOCUP00000002538 | ENSOCUP00000015665 | Apoptosis inducing factor mitochondria associated 1. | D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids (By similarity). | 0.685 |
AIFM1 | GLDC | ENSOCUP00000002538 | ENSOCUP00000003560 | Apoptosis inducing factor mitochondria associated 1. | Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.624 |
AIFM1 | SHMT1 | ENSOCUP00000002538 | ENSOCUP00000017814 | Apoptosis inducing factor mitochondria associated 1. | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.538 |
AMT | DAO | ENSOCUP00000047502 | ENSOCUP00000015665 | Aminomethyltransferase. | D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids (By similarity). | 0.755 |
AMT | GLDC | ENSOCUP00000047502 | ENSOCUP00000003560 | Aminomethyltransferase. | Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.999 |
AMT | HAO1 | ENSOCUP00000047502 | ENSOCUP00000027698 | Aminomethyltransferase. | Hydroxyacid oxidase 1. | 0.463 |
AMT | SHMT1 | ENSOCUP00000047502 | ENSOCUP00000017814 | Aminomethyltransferase. | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.982 |
CTH | DAO | ENSOCUP00000006510 | ENSOCUP00000015665 | Cystathionine gamma-lyase. | D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids (By similarity). | 0.708 |
CTH | DMGDH | ENSOCUP00000006510 | ENSOCUP00000030807 | Cystathionine gamma-lyase. | Dimethylglycine dehydrogenase. | 0.448 |
CTH | SHMT1 | ENSOCUP00000006510 | ENSOCUP00000017814 | Cystathionine gamma-lyase. | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.631 |
CTH | SQOR | ENSOCUP00000006510 | ENSOCUP00000028405 | Cystathionine gamma-lyase. | Pyr_redox_2 domain-containing protein. | 0.712 |
CTH | SRR | ENSOCUP00000006510 | ENSOCUP00000029063 | Cystathionine gamma-lyase. | PALP domain-containing protein. | 0.471 |
DAO | AIFM1 | ENSOCUP00000015665 | ENSOCUP00000002538 | D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids (By similarity). | Apoptosis inducing factor mitochondria associated 1. | 0.685 |
DAO | AMT | ENSOCUP00000015665 | ENSOCUP00000047502 | D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids (By similarity). | Aminomethyltransferase. | 0.755 |
DAO | CTH | ENSOCUP00000015665 | ENSOCUP00000006510 | D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids (By similarity). | Cystathionine gamma-lyase. | 0.708 |
DAO | DMGDH | ENSOCUP00000015665 | ENSOCUP00000030807 | D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids (By similarity). | Dimethylglycine dehydrogenase. | 0.749 |
DAO | ENSOCUP00000044443 | ENSOCUP00000015665 | ENSOCUP00000044443 | D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids (By similarity). | DAO domain-containing protein. | 0.695 |
DAO | GLDC | ENSOCUP00000015665 | ENSOCUP00000003560 | D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids (By similarity). | Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.771 |
DAO | HAO1 | ENSOCUP00000015665 | ENSOCUP00000027698 | D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids (By similarity). | Hydroxyacid oxidase 1. | 0.744 |
DAO | SHMT1 | ENSOCUP00000015665 | ENSOCUP00000017814 | D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids (By similarity). | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.695 |