STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
P15A_RABIT15 kDa protein A; Binds to bacterial lipopolysaccharides (LPS), potentiates strongly the early antibacterial effects of BPI. Inhibits the late lethal action of BPI. (137 aa)    
Predicted Functional Partners:
LAT
Linker for activation of T cells.
      
 0.806
FYN
Tyrosine-protein kinase.
   
 
 0.673
SRC
Tyrosine-protein kinase.
   
 
 0.654
ZAP70
Tyrosine-protein kinase.
   
  
 0.650
G1TM30_RABIT
Uncharacterized protein.
      
 0.649
S100A9
Protein S100-A9; S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid [...]
   
  
 0.600
LOC108175984
Uncharacterized protein.
      
 0.569
ITK
Tyrosine-protein kinase.
   
 
 0.558
SYK
Tyrosine-protein kinase.
   
  
 0.549
LCK
Tyrosine-protein kinase.
   
 
 0.497
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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