node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EDN1 | GNAI1 | ENSOCUP00000011526 | ENSOCUP00000000882 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | G protein subunit alpha i1. | 0.403 |
EDN1 | HTR1B | ENSOCUP00000011526 | ENSOCUP00000016295 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | 5-hydroxytryptamine receptor 1B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopami [...] | 0.795 |
EDN1 | OXT | ENSOCUP00000011526 | ENSOCUP00000045888 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | Oxytocin; Belongs to the vasopressin/oxytocin family. | 0.636 |
GNAI1 | EDN1 | ENSOCUP00000000882 | ENSOCUP00000011526 | G protein subunit alpha i1. | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | 0.403 |
GNAI1 | GNAI2 | ENSOCUP00000000882 | ENSOCUP00000019624 | G protein subunit alpha i1. | G protein subunit alpha i2. | 0.973 |
GNAI1 | GNAI3 | ENSOCUP00000000882 | ENSOCUP00000004821 | G protein subunit alpha i1. | G protein subunit alpha i3. | 0.902 |
GNAI1 | GNB1 | ENSOCUP00000000882 | ENSOCUP00000008676 | G protein subunit alpha i1. | G protein subunit beta 1. | 0.978 |
GNAI1 | GNB3 | ENSOCUP00000000882 | ENSOCUP00000011129 | G protein subunit alpha i1. | G protein subunit beta 3. | 0.933 |
GNAI1 | GNB4 | ENSOCUP00000000882 | ENSOCUP00000000803 | G protein subunit alpha i1. | G protein subunit beta 4. | 0.962 |
GNAI1 | GNB5 | ENSOCUP00000000882 | ENSOCUP00000010220 | G protein subunit alpha i1. | Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, incl [...] | 0.920 |
GNAI1 | GNG4 | ENSOCUP00000000882 | ENSOCUP00000005907 | G protein subunit alpha i1. | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.900 |
GNAI1 | HTR1B | ENSOCUP00000000882 | ENSOCUP00000016295 | G protein subunit alpha i1. | 5-hydroxytryptamine receptor 1B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopami [...] | 0.800 |
GNAI2 | GNAI1 | ENSOCUP00000019624 | ENSOCUP00000000882 | G protein subunit alpha i2. | G protein subunit alpha i1. | 0.973 |
GNAI2 | GNAI3 | ENSOCUP00000019624 | ENSOCUP00000004821 | G protein subunit alpha i2. | G protein subunit alpha i3. | 0.973 |
GNAI2 | GNB1 | ENSOCUP00000019624 | ENSOCUP00000008676 | G protein subunit alpha i2. | G protein subunit beta 1. | 0.979 |
GNAI2 | GNB3 | ENSOCUP00000019624 | ENSOCUP00000011129 | G protein subunit alpha i2. | G protein subunit beta 3. | 0.915 |
GNAI2 | GNB4 | ENSOCUP00000019624 | ENSOCUP00000000803 | G protein subunit alpha i2. | G protein subunit beta 4. | 0.959 |
GNAI2 | GNB5 | ENSOCUP00000019624 | ENSOCUP00000010220 | G protein subunit alpha i2. | Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, incl [...] | 0.905 |
GNAI2 | GNG4 | ENSOCUP00000019624 | ENSOCUP00000005907 | G protein subunit alpha i2. | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.878 |
GNAI2 | HTR1B | ENSOCUP00000019624 | ENSOCUP00000016295 | G protein subunit alpha i2. | 5-hydroxytryptamine receptor 1B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopami [...] | 0.797 |