| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGXT | CBS | ENSOCUP00000022506 | ENSOCUP00000034549 | Serine--pyruvate aminotransferase. | Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). | 0.951 |
| AGXT | CTH | ENSOCUP00000022506 | ENSOCUP00000006510 | Serine--pyruvate aminotransferase. | Cystathionine gamma-lyase. | 0.422 |
| AGXT | G1U159_RABIT | ENSOCUP00000022506 | ENSOCUP00000023092 | Serine--pyruvate aminotransferase. | Beta_elim_lyase domain-containing protein. | 0.993 |
| AGXT | PSPH | ENSOCUP00000022506 | ENSOCUP00000025907 | Serine--pyruvate aminotransferase. | Phosphoserine phosphatase. | 0.991 |
| AGXT | SDS | ENSOCUP00000022506 | ENSOCUP00000018669 | Serine--pyruvate aminotransferase. | Serine dehydratase. | 0.951 |
| AGXT | SHMT1 | ENSOCUP00000022506 | ENSOCUP00000017814 | Serine--pyruvate aminotransferase. | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.991 |
| AGXT | SHMT2 | ENSOCUP00000022506 | ENSOCUP00000019769 | Serine--pyruvate aminotransferase. | Serine hydroxymethyltransferase, mitochondrial; Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis. Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Also required for mitochondrial tran [...] | 0.990 |
| AGXT | SRR | ENSOCUP00000022506 | ENSOCUP00000029063 | Serine--pyruvate aminotransferase. | PALP domain-containing protein. | 0.935 |
| BCAT1 | CBS | ENSOCUP00000033736 | ENSOCUP00000034549 | Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). | 0.450 |
| BCAT1 | CTH | ENSOCUP00000033736 | ENSOCUP00000006510 | Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | Cystathionine gamma-lyase. | 0.946 |
| BCAT1 | G1U159_RABIT | ENSOCUP00000033736 | ENSOCUP00000023092 | Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | Beta_elim_lyase domain-containing protein. | 0.416 |
| BCAT1 | PSPH | ENSOCUP00000033736 | ENSOCUP00000025907 | Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | Phosphoserine phosphatase. | 0.568 |
| BCAT1 | SDS | ENSOCUP00000033736 | ENSOCUP00000018669 | Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | Serine dehydratase. | 0.906 |
| BCAT1 | SHMT1 | ENSOCUP00000033736 | ENSOCUP00000017814 | Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.546 |
| BCAT1 | SHMT2 | ENSOCUP00000033736 | ENSOCUP00000019769 | Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | Serine hydroxymethyltransferase, mitochondrial; Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis. Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Also required for mitochondrial tran [...] | 0.522 |
| BCAT1 | SRR | ENSOCUP00000033736 | ENSOCUP00000029063 | Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | PALP domain-containing protein. | 0.509 |
| CBS | AGXT | ENSOCUP00000034549 | ENSOCUP00000022506 | Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). | Serine--pyruvate aminotransferase. | 0.951 |
| CBS | BCAT1 | ENSOCUP00000034549 | ENSOCUP00000033736 | Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). | Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.450 |
| CBS | CTH | ENSOCUP00000034549 | ENSOCUP00000006510 | Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). | Cystathionine gamma-lyase. | 0.999 |
| CBS | G1U159_RABIT | ENSOCUP00000034549 | ENSOCUP00000023092 | Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). | Beta_elim_lyase domain-containing protein. | 0.534 |