G1TQB6_RABIT protein (Oryctolagus cuniculus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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Coexpression

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[Homology]

Score

G1TQB6_RABIT

Uncharacterized protein. (134 aa)

Predicted Functional Partners:

AGT

0.639

LAMP1

0.628

CTSB

0.626

ATP6AP2

0.543

ISG15

0.542

IDE

0.524

INS

0.522

CXCR4

0.495

CTSH

0.495

G1TLQ5_RABIT

0.449

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGT	ATP6AP2	ENSOCUP00000000417	ENSOCUP00000013112	Angiotensinogen; Belongs to the serpin family.	ATPase H+ transporting accessory protein 2.	0.936
AGT	CTSB	ENSOCUP00000000417	ENSOCUP00000032081	Angiotensinogen; Belongs to the serpin family.	Cathepsin B; Belongs to the peptidase C1 family.	0.630
AGT	CTSH	ENSOCUP00000000417	ENSOCUP00000032495	Angiotensinogen; Belongs to the serpin family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.401
AGT	CXCR4	ENSOCUP00000000417	ENSOCUP00000001655	Angiotensinogen; Belongs to the serpin family.	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.920
AGT	G1TQB6_RABIT	ENSOCUP00000000417	ENSOCUP00000019211	Angiotensinogen; Belongs to the serpin family.	Uncharacterized protein.	0.639
AGT	INS	ENSOCUP00000000417	ENSOCUP00000020463	Angiotensinogen; Belongs to the serpin family.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.561
ATP6AP2	AGT	ENSOCUP00000013112	ENSOCUP00000000417	ATPase H+ transporting accessory protein 2.	Angiotensinogen; Belongs to the serpin family.	0.936
ATP6AP2	G1TQB6_RABIT	ENSOCUP00000013112	ENSOCUP00000019211	ATPase H+ transporting accessory protein 2.	Uncharacterized protein.	0.543
CTSB	AGT	ENSOCUP00000032081	ENSOCUP00000000417	Cathepsin B; Belongs to the peptidase C1 family.	Angiotensinogen; Belongs to the serpin family.	0.630
CTSB	CTSH	ENSOCUP00000032081	ENSOCUP00000032495	Cathepsin B; Belongs to the peptidase C1 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.882
CTSB	G1TQB6_RABIT	ENSOCUP00000032081	ENSOCUP00000019211	Cathepsin B; Belongs to the peptidase C1 family.	Uncharacterized protein.	0.626
CTSB	INS	ENSOCUP00000032081	ENSOCUP00000020463	Cathepsin B; Belongs to the peptidase C1 family.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.414
CTSB	LAMP1	ENSOCUP00000032081	ENSOCUP00000019802	Cathepsin B; Belongs to the peptidase C1 family.	Lysosomal associated membrane protein 1.	0.899
CTSH	AGT	ENSOCUP00000032495	ENSOCUP00000000417	Uncharacterized protein; Belongs to the peptidase C1 family.	Angiotensinogen; Belongs to the serpin family.	0.401
CTSH	CTSB	ENSOCUP00000032495	ENSOCUP00000032081	Uncharacterized protein; Belongs to the peptidase C1 family.	Cathepsin B; Belongs to the peptidase C1 family.	0.882
CTSH	G1TQB6_RABIT	ENSOCUP00000032495	ENSOCUP00000019211	Uncharacterized protein; Belongs to the peptidase C1 family.	Uncharacterized protein.	0.495
CTSH	LAMP1	ENSOCUP00000032495	ENSOCUP00000019802	Uncharacterized protein; Belongs to the peptidase C1 family.	Lysosomal associated membrane protein 1.	0.410
CXCR4	AGT	ENSOCUP00000001655	ENSOCUP00000000417	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	Angiotensinogen; Belongs to the serpin family.	0.920
CXCR4	G1TQB6_RABIT	ENSOCUP00000001655	ENSOCUP00000019211	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.495
CXCR4	INS	ENSOCUP00000001655	ENSOCUP00000020463	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.618

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

12

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009084

Glutamine family amino acid biosynthetic process

4 of 19

2.73

3.41

4.52e-07

GO:0008652

Cellular amino acid biosynthetic process

5 of 63

2.31

3.32

2.63e-07

GO:0019240

Citrulline biosynthetic process

3 of 3

3.41

3.11

2.40e-06

GO:0006591

Ornithine metabolic process

3 of 11

2.84

2.55

2.16e-05

GO:0006592

Ornithine biosynthetic process

2 of 2

3.41

1.9

0.00038

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004350

glutamate-5-semialdehyde dehydrogenase activity

2 of 2

3.41

1.65

0.0011

GO:0004349

Glutamate 5-kinase activity

2 of 2

3.41

1.65

0.0011

GO:0004128

cytochrome-b5 reductase activity, acting on NAD(P)H

2 of 2

3.41

1.65

0.0011

GO:0016491

Oxidoreductase activity

7 of 900

1.3

1.45

2.79e-05

GO:0036094

Small molecule binding

7 of 3203

0.75

0.49

0.0162

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005743

Mitochondrial inner membrane

4 of 438

1.37

0.74

0.0229

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:34185272

(2021) Potential application and beneficial effects of a marine microalgal biomass produced in a high-rate algal pond (HRAP) in diets of European sea bass, Dicentrarchus labrax.

2 of 2

3.41

1.33

0.0040

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:13676

Mixed, incl. Arginine biosynthesis, and Metal-dependent hydrolase, composite domain superfamily

10 of 63

2.61

10.16

4.57e-22

CL:13751

Mixed, incl. De novo UMP biosynthetic process, and Hydantoinase/dihydropyrimidinase

6 of 24

2.81

6.37

7.61e-13

CL:13760

Mixed, incl. De novo UMP biosynthetic process, and Protein transport protein Got1

5 of 13

2.99

5.62

3.87e-11

CL:13763

De novo UMP biosynthetic process, and Oxidoreductase FAD-binding domain

4 of 7

3.16

4.6

4.00e-09

CL:13680

Arginine biosynthesis, and Proline biosynthetic process

4 of 30

2.53

3.33

4.79e-07

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

onl01230

Biosynthesis of amino acids

4 of 89

2.06

2.54

6.00e-06

onl00220

Arginine biosynthesis

2 of 26

2.29

1.36

0.0029

onl00520

Amino sugar and nucleotide sugar metabolism

2 of 54

1.98

1.07

0.0088

onl00330

Arginine and proline metabolism

2 of 54

1.98

1.07

0.0088

onl01100

Metabolic pathways

7 of 1655

1.03

1.04

5.48e-05

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1480926

O2/CO2 exchange in erythrocytes

3 of 36

2.33

1.69

0.00067

MAP-1237044

Erythrocytes take up carbon dioxide and release oxygen

3 of 36

2.33

1.69

0.00067

MAP-70635

Urea cycle

2 of 9

2.75

1.31

0.0042

MAP-8964539

Glutamate and glutamine metabolism

2 of 22

2.37

1.09

0.0097

MAP-71291

Metabolism of amino acids and derivatives

4 of 380

1.43

1.03

0.0043

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005739

Mitochondrion

5 of 992

1.11

0.68

0.0165

GOCC:0005737

Cytoplasm

10 of 6894

0.57

0.4

0.0104

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0285

Flavoprotein

5 of 68

2.27

3.84

1.54e-08

KW-0560

Oxidoreductase

6 of 226

1.83

3.12

2.17e-08

KW-0274

FAD

4 of 61

2.22

3.01

9.31e-07

KW-0521

NADP

3 of 35

2.34

2.36

3.07e-05

KW-0641

Proline biosynthesis

2 of 5

3.01

2.05

0.00019

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00175

Oxidoreductase NAD-binding domain

3 of 7

3.04

2.7

1.26e-05

PF00970

Oxidoreductase FAD-binding domain

2 of 2

3.41

1.67

0.00099

PF00696

Amino acid kinase family

2 of 2

3.41

1.67

0.00099

PF00171

Aldehyde dehydrogenase family

2 of 23

2.35

0.88

0.0246

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001433

Oxidoreductase FAD/NAD(P)-binding

3 of 7

3.04

2.47

3.24e-05

IPR039261

Ferredoxin-NADP reductase (FNR), nucleotide-binding domain

3 of 12

2.81

2.3

6.13e-05

IPR017938

Riboflavin synthase-like beta-barrel

3 of 12

2.81

2.3

6.13e-05

IPR017927

FAD-binding domain, ferredoxin reductase-type

3 of 12

2.81

2.3

6.13e-05

IPR041744

Bifunctional delta 1-pyrroline-5-carboxylate synthetase, glutamate-5-kinase domain

2 of 2

3.41

1.67

0.0010

(more ...)

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