node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADRA2B | DUSP2 | ENSOCUP00000019310 | ENSOCUP00000000098 | Alpha-2B adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.674 |
ADRA2B | ENSOCUP00000049706 | ENSOCUP00000019310 | ENSOCUP00000049706 | Alpha-2B adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.608 |
ADRA2B | GNA12 | ENSOCUP00000019310 | ENSOCUP00000001272 | Alpha-2B adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. | G protein subunit alpha 12. | 0.922 |
ADRA2B | GNA13 | ENSOCUP00000019310 | ENSOCUP00000006607 | Alpha-2B adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. | G protein subunit alpha 13. | 0.922 |
ADRA2B | GNAQ | ENSOCUP00000019310 | ENSOCUP00000014234 | Alpha-2B adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. | G protein subunit alpha q. | 0.924 |
ADRA2B | GNB3 | ENSOCUP00000019310 | ENSOCUP00000011129 | Alpha-2B adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. | G protein subunit beta 3. | 0.637 |
ADRA2B | GNB5 | ENSOCUP00000019310 | ENSOCUP00000010220 | Alpha-2B adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. | Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, incl [...] | 0.652 |
ADRA2B | GNG4 | ENSOCUP00000019310 | ENSOCUP00000005907 | Alpha-2B adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.608 |
ADRA2B | RBP3 | ENSOCUP00000019310 | ENSOCUP00000011711 | Alpha-2B adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. | Retinol-binding protein 3; IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina. | 0.648 |
ADRA2B | SEC24C | ENSOCUP00000019310 | ENSOCUP00000047804 | Alpha-2B adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. | Uncharacterized protein. | 0.644 |
DUSP2 | ADRA2B | ENSOCUP00000000098 | ENSOCUP00000019310 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Alpha-2B adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. | 0.674 |
ENSOCUP00000049706 | ADRA2B | ENSOCUP00000049706 | ENSOCUP00000019310 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | Alpha-2B adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. | 0.608 |
ENSOCUP00000049706 | GNA12 | ENSOCUP00000049706 | ENSOCUP00000001272 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | G protein subunit alpha 12. | 0.679 |
ENSOCUP00000049706 | GNA13 | ENSOCUP00000049706 | ENSOCUP00000006607 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | G protein subunit alpha 13. | 0.761 |
ENSOCUP00000049706 | GNAQ | ENSOCUP00000049706 | ENSOCUP00000014234 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | G protein subunit alpha q. | 0.739 |
ENSOCUP00000049706 | GNB3 | ENSOCUP00000049706 | ENSOCUP00000011129 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | G protein subunit beta 3. | 0.883 |
ENSOCUP00000049706 | GNB5 | ENSOCUP00000049706 | ENSOCUP00000010220 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, incl [...] | 0.854 |
GNA12 | ADRA2B | ENSOCUP00000001272 | ENSOCUP00000019310 | G protein subunit alpha 12. | Alpha-2B adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. | 0.922 |
GNA12 | ENSOCUP00000049706 | ENSOCUP00000001272 | ENSOCUP00000049706 | G protein subunit alpha 12. | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.679 |
GNA12 | GNA13 | ENSOCUP00000001272 | ENSOCUP00000006607 | G protein subunit alpha 12. | G protein subunit alpha 13. | 0.984 |