node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALDH1A2 | CYP26A1 | ENSOCUP00000014561 | ENSOCUP00000000158 | Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. | Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. | 0.975 |
ALDH1A2 | DHRS3 | ENSOCUP00000014561 | ENSOCUP00000026481 | Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.938 |
ALDH1A2 | DHRS4 | ENSOCUP00000014561 | ENSOCUP00000019647 | Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. | Dehydrogenase/reductase SDR family member 4; Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha- dicarbonyl compounds with aromatic rings, such as pyrimidine-4- aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4- hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones. | 0.927 |
ALDH1A2 | DHRS9 | ENSOCUP00000014561 | ENSOCUP00000004912 | Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. | Dehydrogenase/reductase 9; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.924 |
ALDH1A2 | ENSOCUP00000035026 | ENSOCUP00000014561 | ENSOCUP00000035026 | Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.928 |
ALDH1A2 | RETSAT | ENSOCUP00000014561 | ENSOCUP00000016024 | Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. | Retinol saturase. | 0.401 |
AOX1 | AOX2 | ENSOCUP00000046241 | ENSOCUP00000025105 | Aldehyde oxidase 1; Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen specie [...] | Aldehyde oxidase 3L1. | 0.903 |
AOX1 | CYP26A1 | ENSOCUP00000046241 | ENSOCUP00000000158 | Aldehyde oxidase 1; Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen specie [...] | Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. | 0.912 |
AOX1 | DHRS3 | ENSOCUP00000046241 | ENSOCUP00000026481 | Aldehyde oxidase 1; Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen specie [...] | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.904 |
AOX1 | DHRS4 | ENSOCUP00000046241 | ENSOCUP00000019647 | Aldehyde oxidase 1; Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen specie [...] | Dehydrogenase/reductase SDR family member 4; Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha- dicarbonyl compounds with aromatic rings, such as pyrimidine-4- aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4- hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones. | 0.949 |
AOX1 | DHRS9 | ENSOCUP00000046241 | ENSOCUP00000004912 | Aldehyde oxidase 1; Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen specie [...] | Dehydrogenase/reductase 9; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.900 |
AOX1 | ENSOCUP00000035026 | ENSOCUP00000046241 | ENSOCUP00000035026 | Aldehyde oxidase 1; Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen specie [...] | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.904 |
AOX2 | AOX1 | ENSOCUP00000025105 | ENSOCUP00000046241 | Aldehyde oxidase 3L1. | Aldehyde oxidase 1; Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen specie [...] | 0.903 |
AOX2 | CYP26A1 | ENSOCUP00000025105 | ENSOCUP00000000158 | Aldehyde oxidase 3L1. | Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. | 0.912 |
AOX2 | DHRS3 | ENSOCUP00000025105 | ENSOCUP00000026481 | Aldehyde oxidase 3L1. | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.904 |
AOX2 | DHRS4 | ENSOCUP00000025105 | ENSOCUP00000019647 | Aldehyde oxidase 3L1. | Dehydrogenase/reductase SDR family member 4; Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha- dicarbonyl compounds with aromatic rings, such as pyrimidine-4- aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4- hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones. | 0.927 |
AOX2 | DHRS9 | ENSOCUP00000025105 | ENSOCUP00000004912 | Aldehyde oxidase 3L1. | Dehydrogenase/reductase 9; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.900 |
AOX2 | ENSOCUP00000035026 | ENSOCUP00000025105 | ENSOCUP00000035026 | Aldehyde oxidase 3L1. | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.904 |
CYP26A1 | ALDH1A2 | ENSOCUP00000000158 | ENSOCUP00000014561 | Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. | Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. | 0.975 |
CYP26A1 | AOX1 | ENSOCUP00000000158 | ENSOCUP00000046241 | Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. | Aldehyde oxidase 1; Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen specie [...] | 0.912 |