NKX6-1 protein (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FOXA2	GCG	ENSOCUP00000006365	ENSOCUP00000019727	Forkhead box A2.	Glucagon; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis (By similarity).	0.659
FOXA2	INS	ENSOCUP00000006365	ENSOCUP00000020463	Forkhead box A2.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.764
FOXA2	ISL1	ENSOCUP00000006365	ENSOCUP00000020036	Forkhead box A2.	ISL LIM homeobox 1.	0.720
FOXA2	MAFB	ENSOCUP00000006365	ENSOCUP00000022550	Forkhead box A2.	MAF bZIP transcription factor B.	0.521
FOXA2	NEUROD1	ENSOCUP00000006365	ENSOCUP00000044556	Forkhead box A2.	BHLH domain-containing protein.	0.652
FOXA2	NKX2-2	ENSOCUP00000006365	ENSOCUP00000019073	Forkhead box A2.	NK2 homeobox 2.	0.704
FOXA2	NKX6-1	ENSOCUP00000006365	ENSOCUP00000019963	Forkhead box A2.	NK6 homeobox 1.	0.629
FOXA2	PDX1	ENSOCUP00000006365	ENSOCUP00000004229	Forkhead box A2.	Pancreatic and duodenal homeobox 1.	0.819
FOXA2	SLC2A2	ENSOCUP00000006365	ENSOCUP00000003957	Forkhead box A2.	Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	0.472
FOXA2	SST	ENSOCUP00000006365	ENSOCUP00000006540	Forkhead box A2.	Somatostatin.	0.475
GCG	FOXA2	ENSOCUP00000019727	ENSOCUP00000006365	Glucagon; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis (By similarity).	Forkhead box A2.	0.659
GCG	INS	ENSOCUP00000019727	ENSOCUP00000020463	Glucagon; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis (By similarity).	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.962
GCG	ISL1	ENSOCUP00000019727	ENSOCUP00000020036	Glucagon; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis (By similarity).	ISL LIM homeobox 1.	0.600
GCG	MAFB	ENSOCUP00000019727	ENSOCUP00000022550	Glucagon; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis (By similarity).	MAF bZIP transcription factor B.	0.701
GCG	NEUROD1	ENSOCUP00000019727	ENSOCUP00000044556	Glucagon; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis (By similarity).	BHLH domain-containing protein.	0.687
GCG	NKX2-2	ENSOCUP00000019727	ENSOCUP00000019073	Glucagon; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis (By similarity).	NK2 homeobox 2.	0.549
GCG	NKX6-1	ENSOCUP00000019727	ENSOCUP00000019963	Glucagon; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis (By similarity).	NK6 homeobox 1.	0.673
GCG	PDX1	ENSOCUP00000019727	ENSOCUP00000004229	Glucagon; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis (By similarity).	Pancreatic and duodenal homeobox 1.	0.772
GCG	SLC2A2	ENSOCUP00000019727	ENSOCUP00000003957	Glucagon; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis (By similarity).	Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	0.744
GCG	SST	ENSOCUP00000019727	ENSOCUP00000006540	Glucagon; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis (By similarity).	Somatostatin.	0.931