node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAN | ALPL | ENSOCUP00000024918 | ENSOCUP00000003846 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Alkaline phosphatase. | 0.665 |
ACAN | BGLAP | ENSOCUP00000024918 | ENSOCUP00000020318 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | 0.861 |
ACAN | BMP2 | ENSOCUP00000024918 | ENSOCUP00000010036 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4. | 0.764 |
ACAN | IBSP | ENSOCUP00000024918 | ENSOCUP00000000906 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Integrin binding sialoprotein. | 0.560 |
ACAN | PTH | ENSOCUP00000024918 | ENSOCUP00000004740 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Parathyroid hormone. | 0.445 |
ACAN | RUNX2 | ENSOCUP00000024918 | ENSOCUP00000010093 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | RUNX family transcription factor 2. | 0.851 |
ACAN | SOST | ENSOCUP00000024918 | ENSOCUP00000002558 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Sclerostin. | 0.426 |
ACAN | SPARC | ENSOCUP00000024918 | ENSOCUP00000010426 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | SPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity); Belongs to the SPARC family. | 0.631 |
ACAN | SPP1 | ENSOCUP00000024918 | ENSOCUP00000021885 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. | 0.742 |
ALPL | ACAN | ENSOCUP00000003846 | ENSOCUP00000024918 | Alkaline phosphatase. | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | 0.665 |
ALPL | BGLAP | ENSOCUP00000003846 | ENSOCUP00000020318 | Alkaline phosphatase. | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | 0.858 |
ALPL | BMP2 | ENSOCUP00000003846 | ENSOCUP00000010036 | Alkaline phosphatase. | Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4. | 0.615 |
ALPL | IBSP | ENSOCUP00000003846 | ENSOCUP00000000906 | Alkaline phosphatase. | Integrin binding sialoprotein. | 0.813 |
ALPL | PTH | ENSOCUP00000003846 | ENSOCUP00000004740 | Alkaline phosphatase. | Parathyroid hormone. | 0.448 |
ALPL | RUNX2 | ENSOCUP00000003846 | ENSOCUP00000010093 | Alkaline phosphatase. | RUNX family transcription factor 2. | 0.852 |
ALPL | SOST | ENSOCUP00000003846 | ENSOCUP00000002558 | Alkaline phosphatase. | Sclerostin. | 0.719 |
ALPL | SPARC | ENSOCUP00000003846 | ENSOCUP00000010426 | Alkaline phosphatase. | SPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity); Belongs to the SPARC family. | 0.534 |
ALPL | SPP1 | ENSOCUP00000003846 | ENSOCUP00000021885 | Alkaline phosphatase. | Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family. | 0.704 |
BGLAP | ACAN | ENSOCUP00000020318 | ENSOCUP00000024918 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | 0.861 |
BGLAP | ALPL | ENSOCUP00000020318 | ENSOCUP00000003846 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Alkaline phosphatase. | 0.858 |