| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DHX30 | MRPL36 | ENSOCUP00000005636 | ENSOCUP00000020265 | DExH-box helicase 30. | Ribosomal protein; Belongs to the bacterial ribosomal protein bL36 family. | 0.593 |
| DHX30 | POLG2 | ENSOCUP00000005636 | ENSOCUP00000032567 | DExH-box helicase 30. | DNA polymerase gamma 2, accessory subunit. | 0.527 |
| DHX30 | SSBP1 | ENSOCUP00000005636 | ENSOCUP00000021419 | DExH-box helicase 30. | Single-stranded DNA-binding protein, mitochondrial; Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays crucial roles during mtDNA replication that stimulate activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5 [...] | 0.731 |
| DHX30 | TFAM | ENSOCUP00000005636 | ENSOCUP00000012385 | DExH-box helicase 30. | Transcription factor A, mitochondrial. | 0.483 |
| MRPL36 | DHX30 | ENSOCUP00000020265 | ENSOCUP00000005636 | Ribosomal protein; Belongs to the bacterial ribosomal protein bL36 family. | DExH-box helicase 30. | 0.593 |
| MRPL36 | SSBP1 | ENSOCUP00000020265 | ENSOCUP00000021419 | Ribosomal protein; Belongs to the bacterial ribosomal protein bL36 family. | Single-stranded DNA-binding protein, mitochondrial; Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays crucial roles during mtDNA replication that stimulate activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5 [...] | 0.687 |
| MRPL36 | TOP3A | ENSOCUP00000020265 | ENSOCUP00000005547 | Ribosomal protein; Belongs to the bacterial ribosomal protein bL36 family. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.487 |
| POLG | POLG2 | ENSOCUP00000049652 | ENSOCUP00000032567 | DNA polymerase gamma, catalytic subunit. | DNA polymerase gamma 2, accessory subunit. | 0.991 |
| POLG | RNASEH1 | ENSOCUP00000049652 | ENSOCUP00000005300 | DNA polymerase gamma, catalytic subunit. | Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.530 |
| POLG | SSBP1 | ENSOCUP00000049652 | ENSOCUP00000021419 | DNA polymerase gamma, catalytic subunit. | Single-stranded DNA-binding protein, mitochondrial; Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays crucial roles during mtDNA replication that stimulate activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5 [...] | 0.798 |
| POLG | TFAM | ENSOCUP00000049652 | ENSOCUP00000012385 | DNA polymerase gamma, catalytic subunit. | Transcription factor A, mitochondrial. | 0.877 |
| POLG2 | DHX30 | ENSOCUP00000032567 | ENSOCUP00000005636 | DNA polymerase gamma 2, accessory subunit. | DExH-box helicase 30. | 0.527 |
| POLG2 | POLG | ENSOCUP00000032567 | ENSOCUP00000049652 | DNA polymerase gamma 2, accessory subunit. | DNA polymerase gamma, catalytic subunit. | 0.991 |
| POLG2 | RNASEH1 | ENSOCUP00000032567 | ENSOCUP00000005300 | DNA polymerase gamma 2, accessory subunit. | Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.616 |
| POLG2 | SSBP1 | ENSOCUP00000032567 | ENSOCUP00000021419 | DNA polymerase gamma 2, accessory subunit. | Single-stranded DNA-binding protein, mitochondrial; Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays crucial roles during mtDNA replication that stimulate activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5 [...] | 0.747 |
| POLG2 | TFAM | ENSOCUP00000032567 | ENSOCUP00000012385 | DNA polymerase gamma 2, accessory subunit. | Transcription factor A, mitochondrial. | 0.728 |
| POLG2 | YARS1 | ENSOCUP00000032567 | ENSOCUP00000008622 | DNA polymerase gamma 2, accessory subunit. | Tyrosine--tRNA ligase. | 0.924 |
| PRIMPOL | RAD52 | ENSOCUP00000003383 | ENSOCUP00000011685 | Uncharacterized protein. | RAD52 homolog, DNA repair protein. | 0.427 |
| PRIMPOL | SSBP1 | ENSOCUP00000003383 | ENSOCUP00000021419 | Uncharacterized protein. | Single-stranded DNA-binding protein, mitochondrial; Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays crucial roles during mtDNA replication that stimulate activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5 [...] | 0.663 |
| PRIMPOL | TOP3A | ENSOCUP00000003383 | ENSOCUP00000005547 | Uncharacterized protein. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.474 |