| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACE2 | AGT | ENSOCUP00000015275 | ENSOCUP00000000417 | Angiotensin-converting enzyme. | Angiotensinogen; Belongs to the serpin family. | 0.985 |
| ACE2 | IDE | ENSOCUP00000015275 | ENSOCUP00000030432 | Angiotensin-converting enzyme. | Insulin degrading enzyme; Belongs to the peptidase M16 family. | 0.555 |
| ACE2 | MEP1A | ENSOCUP00000015275 | ENSOCUP00000001280 | Angiotensin-converting enzyme. | Meprin A subunit. | 0.934 |
| ACE2 | MEP1B | ENSOCUP00000015275 | ENSOCUP00000011831 | Angiotensin-converting enzyme. | Meprin A subunit. | 0.931 |
| ACE2 | MME | ENSOCUP00000015275 | ENSOCUP00000041310 | Angiotensin-converting enzyme. | Neprilysin; Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers. Belongs to the peptidase M13 family. | 0.985 |
| ACE2 | PRCP | ENSOCUP00000015275 | ENSOCUP00000044768 | Angiotensin-converting enzyme. | Prolylcarboxypeptidase. | 0.958 |
| ACE2 | XPNPEP2 | ENSOCUP00000015275 | ENSOCUP00000022176 | Angiotensin-converting enzyme. | X-prolyl aminopeptidase 2; Belongs to the peptidase M24B family. | 0.918 |
| AGT | ACE2 | ENSOCUP00000000417 | ENSOCUP00000015275 | Angiotensinogen; Belongs to the serpin family. | Angiotensin-converting enzyme. | 0.985 |
| AGT | APP | ENSOCUP00000000417 | ENSOCUP00000009130 | Angiotensinogen; Belongs to the serpin family. | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.498 |
| AGT | MME | ENSOCUP00000000417 | ENSOCUP00000041310 | Angiotensinogen; Belongs to the serpin family. | Neprilysin; Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers. Belongs to the peptidase M13 family. | 0.862 |
| APP | AGT | ENSOCUP00000009130 | ENSOCUP00000000417 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Angiotensinogen; Belongs to the serpin family. | 0.498 |
| APP | IDE | ENSOCUP00000009130 | ENSOCUP00000030432 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Insulin degrading enzyme; Belongs to the peptidase M16 family. | 0.977 |
| APP | MME | ENSOCUP00000009130 | ENSOCUP00000041310 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Neprilysin; Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers. Belongs to the peptidase M13 family. | 0.853 |
| APP | XPNPEP2 | ENSOCUP00000009130 | ENSOCUP00000022176 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | X-prolyl aminopeptidase 2; Belongs to the peptidase M24B family. | 0.454 |
| BCL6 | CD19 | ENSOCUP00000045134 | ENSOCUP00000036537 | BCL6 transcription repressor. | CD19 molecule. | 0.781 |
| BCL6 | MME | ENSOCUP00000045134 | ENSOCUP00000041310 | BCL6 transcription repressor. | Neprilysin; Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers. Belongs to the peptidase M13 family. | 0.853 |
| CD19 | BCL6 | ENSOCUP00000036537 | ENSOCUP00000045134 | CD19 molecule. | BCL6 transcription repressor. | 0.781 |
| CD19 | MME | ENSOCUP00000036537 | ENSOCUP00000041310 | CD19 molecule. | Neprilysin; Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers. Belongs to the peptidase M13 family. | 0.874 |
| IDE | ACE2 | ENSOCUP00000030432 | ENSOCUP00000015275 | Insulin degrading enzyme; Belongs to the peptidase M16 family. | Angiotensin-converting enzyme. | 0.555 |
| IDE | APP | ENSOCUP00000030432 | ENSOCUP00000009130 | Insulin degrading enzyme; Belongs to the peptidase M16 family. | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.977 |