node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CA2 | SLC9A1 | ENSOCUP00000032692 | ENSOCUP00000022999 | Carbonic anhydrase 2; Essential for bone resorption and osteoclast differentiation. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6 (By similarity). Reversible hydration of carbon dioxide; Belongs to the alpha-carbonic anhydrase family. | Sodium/hydrogen exchanger 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. | 0.944 |
CHP1 | SLC9A1 | ENSOCUP00000011896 | ENSOCUP00000022999 | Calcineurin like EF-hand protein 1. | Sodium/hydrogen exchanger 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. | 0.939 |
CHP1 | SLC9A4 | ENSOCUP00000011896 | ENSOCUP00000005263 | Calcineurin like EF-hand protein 1. | Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. | 0.668 |
CHP2 | SLC9A1 | ENSOCUP00000030225 | ENSOCUP00000022999 | Calcineurin like EF-hand protein 2. | Sodium/hydrogen exchanger 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. | 0.934 |
CHP2 | SLC9A4 | ENSOCUP00000030225 | ENSOCUP00000005263 | Calcineurin like EF-hand protein 2. | Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. | 0.652 |
EZR | MSN | ENSOCUP00000040029 | ENSOCUP00000000131 | Ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane (By similarity). In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity). | FERM domain-containing protein. | 0.999 |
EZR | PRKACB | ENSOCUP00000040029 | ENSOCUP00000043583 | Ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane (By similarity). In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity). | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. | 0.979 |
EZR | RDX | ENSOCUP00000040029 | ENSOCUP00000037499 | Ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane (By similarity). In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity). | Radixin. | 0.999 |
EZR | ROCK1 | ENSOCUP00000040029 | ENSOCUP00000034408 | Ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane (By similarity). In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity). | Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity (By similarity). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (By similarity). Phosphorylates FHOD1 and acts synergistically with it to promote SRC- dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 [...] | 0.626 |
EZR | SLC9A1 | ENSOCUP00000040029 | ENSOCUP00000022999 | Ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane (By similarity). In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity). | Sodium/hydrogen exchanger 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. | 0.990 |
MAPK1 | PRKACB | ENSOCUP00000011783 | ENSOCUP00000043583 | Mitogen-activated protein kinase. | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. | 0.937 |
MAPK1 | ROCK1 | ENSOCUP00000011783 | ENSOCUP00000034408 | Mitogen-activated protein kinase. | Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity (By similarity). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (By similarity). Phosphorylates FHOD1 and acts synergistically with it to promote SRC- dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 [...] | 0.921 |
MAPK1 | SLC9A1 | ENSOCUP00000011783 | ENSOCUP00000022999 | Mitogen-activated protein kinase. | Sodium/hydrogen exchanger 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. | 0.909 |
MSN | EZR | ENSOCUP00000000131 | ENSOCUP00000040029 | FERM domain-containing protein. | Ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane (By similarity). In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity). | 0.999 |
MSN | PRKACB | ENSOCUP00000000131 | ENSOCUP00000043583 | FERM domain-containing protein. | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. | 0.461 |
MSN | RDX | ENSOCUP00000000131 | ENSOCUP00000037499 | FERM domain-containing protein. | Radixin. | 0.999 |
MSN | ROCK1 | ENSOCUP00000000131 | ENSOCUP00000034408 | FERM domain-containing protein. | Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity (By similarity). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (By similarity). Phosphorylates FHOD1 and acts synergistically with it to promote SRC- dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 [...] | 0.680 |
MSN | SLC9A1 | ENSOCUP00000000131 | ENSOCUP00000022999 | FERM domain-containing protein. | Sodium/hydrogen exchanger 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. | 0.987 |
PRKACB | EZR | ENSOCUP00000043583 | ENSOCUP00000040029 | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. | Ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane (By similarity). In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity). | 0.979 |
PRKACB | MAPK1 | ENSOCUP00000043583 | ENSOCUP00000011783 | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase. | 0.937 |