STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PLAUUrokinase-type plasminogen activator short chain A; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin; Belongs to the peptidase S1 family. (433 aa)    
Predicted Functional Partners:
PLAUR
Plasminogen activator, urokinase receptor.
   
 0.999
SERPINE1
Serpin family E member 1; Belongs to the serpin family.
   
 0.997
SERPINE2
Serpin family E member 2; Belongs to the serpin family.
   
 0.982
PLG
Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]
  
 
0.970
SERPINB2
Serine proteinase inhibitor, clade B, member 2 (Predicted); Belongs to the serpin family.
    
 0.966
SERPINA5
SERPIN domain-containing protein; Belongs to the serpin family.
    
 0.899
G1U8B5_RABIT
Uncharacterized protein.
 
  
  0.888
SERPING1
Plasma protease C1 inhibitor; Belongs to the serpin family.
   
 0.878
SERPINA3
Serpin family A member 3; Belongs to the serpin family.
    
 0.849
A2M
Alpha-2-macroglobulin.
    
 0.830
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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