PPP2R5C protein (Oryctolagus cuniculus) - STRING interaction network

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PPP2R5C

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A- PPP2R5C holoenzyme may activate TP53 and play a role in DNA damage- induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation (By similarity). (542 aa)

Predicted Functional Partners:

PPP2R1B

0.997

PPP2CA

0.996

SGO1

0.985

PPP2R1A

0.980

BUB1B

0.956

AKT3

0.945

PPP2R2A

0.908

BCL2

0.906

RYR2

0.900

PTPA

0.885

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT3	BCL2	ENSOCUP00000041212	ENSOCUP00000036189	Non-specific serine/threonine protein kinase.	BH4_2 domain-containing protein.	0.955
AKT3	PPP2CA	ENSOCUP00000041212	ENSOCUP00000013713	Non-specific serine/threonine protein kinase.	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity).	0.955
AKT3	PPP2R1A	ENSOCUP00000041212	ENSOCUP00000014689	Non-specific serine/threonine protein kinase.	Protein phosphatase 2 scaffold subunit Aalpha.	0.954
AKT3	PPP2R1B	ENSOCUP00000041212	ENSOCUP00000041612	Non-specific serine/threonine protein kinase.	Protein phosphatase 2 scaffold subunit Abeta.	0.951
AKT3	PPP2R2A	ENSOCUP00000041212	ENSOCUP00000035053	Non-specific serine/threonine protein kinase.	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	0.910
AKT3	PPP2R5C	ENSOCUP00000041212	ENSOCUP00000028766	Non-specific serine/threonine protein kinase.	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A- PPP2R5C holoenzyme may activate TP53 and play a role in DNA damage- induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation (By similarity).	0.945
AKT3	PTPA	ENSOCUP00000041212	ENSOCUP00000044909	Non-specific serine/threonine protein kinase.	Serine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine- protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+). Reversibly stimulates the variable phosphotyr [...]	0.909
BCL2	AKT3	ENSOCUP00000036189	ENSOCUP00000041212	BH4_2 domain-containing protein.	Non-specific serine/threonine protein kinase.	0.955
BCL2	PPP2CA	ENSOCUP00000036189	ENSOCUP00000013713	BH4_2 domain-containing protein.	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity).	0.913
BCL2	PPP2R1A	ENSOCUP00000036189	ENSOCUP00000014689	BH4_2 domain-containing protein.	Protein phosphatase 2 scaffold subunit Aalpha.	0.900
BCL2	PPP2R1B	ENSOCUP00000036189	ENSOCUP00000041612	BH4_2 domain-containing protein.	Protein phosphatase 2 scaffold subunit Abeta.	0.906
BCL2	PPP2R2A	ENSOCUP00000036189	ENSOCUP00000035053	BH4_2 domain-containing protein.	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.	0.912
BCL2	PPP2R5C	ENSOCUP00000036189	ENSOCUP00000028766	BH4_2 domain-containing protein.	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A- PPP2R5C holoenzyme may activate TP53 and play a role in DNA damage- induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation (By similarity).	0.906
BUB1B	PPP2CA	ENSOCUP00000045959	ENSOCUP00000013713	Uncharacterized protein.	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity).	0.736
BUB1B	PPP2R1A	ENSOCUP00000045959	ENSOCUP00000014689	Uncharacterized protein.	Protein phosphatase 2 scaffold subunit Aalpha.	0.412
BUB1B	PPP2R1B	ENSOCUP00000045959	ENSOCUP00000041612	Uncharacterized protein.	Protein phosphatase 2 scaffold subunit Abeta.	0.412
BUB1B	PPP2R5C	ENSOCUP00000045959	ENSOCUP00000028766	Uncharacterized protein.	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A- PPP2R5C holoenzyme may activate TP53 and play a role in DNA damage- induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation (By similarity).	0.956
BUB1B	SGO1	ENSOCUP00000045959	ENSOCUP00000005241	Uncharacterized protein.	Shugoshin 1.	0.898
PPP2CA	AKT3	ENSOCUP00000013713	ENSOCUP00000041212	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity).	Non-specific serine/threonine protein kinase.	0.955
PPP2CA	BCL2	ENSOCUP00000013713	ENSOCUP00000036189	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity).	BH4_2 domain-containing protein.	0.913

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