DNMT3A protein (Oryctolagus cuniculus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASXL1	DNMT3A	ENSOCUP00000023164	ENSOCUP00000024004	ASXL transcriptional regulator 1.	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.871
ASXL1	EZH2	ENSOCUP00000023164	ENSOCUP00000041806	ASXL transcriptional regulator 1.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.901
ASXL1	H3C13	ENSOCUP00000023164	ENSOCUP00000016501	ASXL transcriptional regulator 1.	Histone H3; Belongs to the histone H3 family.	0.521
ASXL1	TET2	ENSOCUP00000023164	ENSOCUP00000006138	ASXL transcriptional regulator 1.	Tet methylcytosine dioxygenase 2.	0.909
DNMT3A	ASXL1	ENSOCUP00000024004	ENSOCUP00000023164	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	ASXL transcriptional regulator 1.	0.871
DNMT3A	DNMT3B	ENSOCUP00000024004	ENSOCUP00000015318	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.992
DNMT3A	ENSOCUP00000032761	ENSOCUP00000024004	ENSOCUP00000032761	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.969
DNMT3A	EZH2	ENSOCUP00000024004	ENSOCUP00000041806	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.969
DNMT3A	GNMT	ENSOCUP00000024004	ENSOCUP00000003341	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Glycine N-methyltransferase; Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.	0.864
DNMT3A	H3C13	ENSOCUP00000024004	ENSOCUP00000016501	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Histone H3; Belongs to the histone H3 family.	0.902
DNMT3A	HDAC1	ENSOCUP00000024004	ENSOCUP00000037903	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.891
DNMT3A	MAT2A	ENSOCUP00000024004	ENSOCUP00000002040	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	0.886
DNMT3A	MAT2B	ENSOCUP00000024004	ENSOCUP00000029684	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.	0.864
DNMT3A	TET2	ENSOCUP00000024004	ENSOCUP00000006138	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Tet methylcytosine dioxygenase 2.	0.904
DNMT3B	DNMT3A	ENSOCUP00000015318	ENSOCUP00000024004	DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.992
DNMT3B	ENSOCUP00000032761	ENSOCUP00000015318	ENSOCUP00000032761	DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.614
DNMT3B	EZH2	ENSOCUP00000015318	ENSOCUP00000041806	DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.966
DNMT3B	GNMT	ENSOCUP00000015318	ENSOCUP00000003341	DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Glycine N-methyltransferase; Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.	0.864
DNMT3B	H3C13	ENSOCUP00000015318	ENSOCUP00000016501	DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Histone H3; Belongs to the histone H3 family.	0.865
DNMT3B	HDAC1	ENSOCUP00000015318	ENSOCUP00000037903	DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.942