node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FN1 | ITGA2B | ENSOCUP00000008718 | ENSOCUP00000002848 | Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). | Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. | 0.995 |
FN1 | ITGA8 | ENSOCUP00000008718 | ENSOCUP00000046120 | Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). | Integrin subunit alpha 8; Belongs to the integrin alpha chain family. | 0.970 |
FN1 | ITGAV | ENSOCUP00000008718 | ENSOCUP00000039361 | Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). | Integrin subunit alpha V; Belongs to the integrin alpha chain family. | 0.998 |
FN1 | ITGB1 | ENSOCUP00000008718 | ENSOCUP00000003143 | Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). | Integrin beta; Belongs to the integrin beta chain family. | 0.999 |
FN1 | ITGB3 | ENSOCUP00000008718 | ENSOCUP00000033109 | Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). | Integrin beta; Belongs to the integrin beta chain family. | 0.998 |
FN1 | ITGB5 | ENSOCUP00000008718 | ENSOCUP00000012560 | Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). | Integrin beta; Belongs to the integrin beta chain family. | 0.991 |
FN1 | ITGB8 | ENSOCUP00000008718 | ENSOCUP00000043357 | Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). | Integrin beta-8; Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta- 1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (By similarity). Required during vasculogenesis (By similarity). | 0.926 |
FN1 | PLAU | ENSOCUP00000008718 | ENSOCUP00000023296 | Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). | Urokinase-type plasminogen activator short chain A; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin; Belongs to the peptidase S1 family. | 0.679 |
FN1 | SERPINE1 | ENSOCUP00000008718 | ENSOCUP00000013814 | Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). | Serpin family E member 1; Belongs to the serpin family. | 0.570 |
FN1 | VTN | ENSOCUP00000008718 | ENSOCUP00000024132 | Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). | Vitronectin; Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. | 0.996 |
ITGA2B | FN1 | ENSOCUP00000002848 | ENSOCUP00000008718 | Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. | Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). | 0.995 |
ITGA2B | ITGAV | ENSOCUP00000002848 | ENSOCUP00000039361 | Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. | Integrin subunit alpha V; Belongs to the integrin alpha chain family. | 0.949 |
ITGA2B | ITGB1 | ENSOCUP00000002848 | ENSOCUP00000003143 | Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. | Integrin beta; Belongs to the integrin beta chain family. | 0.950 |
ITGA2B | ITGB3 | ENSOCUP00000002848 | ENSOCUP00000033109 | Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. | Integrin beta; Belongs to the integrin beta chain family. | 0.999 |
ITGA2B | ITGB5 | ENSOCUP00000002848 | ENSOCUP00000012560 | Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. | Integrin beta; Belongs to the integrin beta chain family. | 0.801 |
ITGA2B | ITGB8 | ENSOCUP00000002848 | ENSOCUP00000043357 | Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. | Integrin beta-8; Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta- 1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (By similarity). Required during vasculogenesis (By similarity). | 0.830 |
ITGA2B | VTN | ENSOCUP00000002848 | ENSOCUP00000024132 | Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. | Vitronectin; Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. | 0.994 |
ITGA8 | FN1 | ENSOCUP00000046120 | ENSOCUP00000008718 | Integrin subunit alpha 8; Belongs to the integrin alpha chain family. | Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). | 0.970 |
ITGA8 | ITGAV | ENSOCUP00000046120 | ENSOCUP00000039361 | Integrin subunit alpha 8; Belongs to the integrin alpha chain family. | Integrin subunit alpha V; Belongs to the integrin alpha chain family. | 0.661 |
ITGA8 | ITGB1 | ENSOCUP00000046120 | ENSOCUP00000003143 | Integrin subunit alpha 8; Belongs to the integrin alpha chain family. | Integrin beta; Belongs to the integrin beta chain family. | 0.991 |