NAT1 protein (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

NAT1

Arylamine N-acetyltransferase 1; Belongs to the arylamine N-acetyltransferase family. (290 aa)

Predicted Functional Partners:

CYP1A2

0.929

XDH

0.917

EST1_RABIT

0.902

MPO

0.900

ESCO1

0.749

ESCO2

0.732

UGT3A2

0.579

HGSNAT

0.537

G1TPR2_RABIT

0.531

GNPNAT1

0.524

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYP1A2	ESCO1	ENSOCUP00000008665	ENSOCUP00000008261	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	Establishment of sister chromatid cohesion N-acetyltransferase 1.	0.435
CYP1A2	ESCO2	ENSOCUP00000008665	ENSOCUP00000008552	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	Establishment of sister chromatid cohesion N-acetyltransferase 2.	0.410
CYP1A2	NAT1	ENSOCUP00000008665	ENSOCUP00000024297	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	Arylamine N-acetyltransferase 1; Belongs to the arylamine N-acetyltransferase family.	0.929
CYP1A2	UGT3A2	ENSOCUP00000008665	ENSOCUP00000009818	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.755
CYP1A2	XDH	ENSOCUP00000008665	ENSOCUP00000001068	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	Uncharacterized protein.	0.919
ESCO1	CYP1A2	ENSOCUP00000008261	ENSOCUP00000008665	Establishment of sister chromatid cohesion N-acetyltransferase 1.	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	0.435
ESCO1	ESCO2	ENSOCUP00000008261	ENSOCUP00000008552	Establishment of sister chromatid cohesion N-acetyltransferase 1.	Establishment of sister chromatid cohesion N-acetyltransferase 2.	0.404
ESCO1	NAT1	ENSOCUP00000008261	ENSOCUP00000024297	Establishment of sister chromatid cohesion N-acetyltransferase 1.	Arylamine N-acetyltransferase 1; Belongs to the arylamine N-acetyltransferase family.	0.749
ESCO1	UGT3A2	ENSOCUP00000008261	ENSOCUP00000009818	Establishment of sister chromatid cohesion N-acetyltransferase 1.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.435
ESCO2	CYP1A2	ENSOCUP00000008552	ENSOCUP00000008665	Establishment of sister chromatid cohesion N-acetyltransferase 2.	Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]	0.410
ESCO2	ESCO1	ENSOCUP00000008552	ENSOCUP00000008261	Establishment of sister chromatid cohesion N-acetyltransferase 2.	Establishment of sister chromatid cohesion N-acetyltransferase 1.	0.404
ESCO2	NAT1	ENSOCUP00000008552	ENSOCUP00000024297	Establishment of sister chromatid cohesion N-acetyltransferase 2.	Arylamine N-acetyltransferase 1; Belongs to the arylamine N-acetyltransferase family.	0.732
ESCO2	UGT3A2	ENSOCUP00000008552	ENSOCUP00000009818	Establishment of sister chromatid cohesion N-acetyltransferase 2.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.408
EST1_RABIT	MPO	ENSOCUP00000040102	ENSOCUP00000043679	Liver carboxylesterase 1; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Belongs to the type-B carboxylesterase/lipase family.	Myeloperoxidase.	0.906
EST1_RABIT	NAT1	ENSOCUP00000040102	ENSOCUP00000024297	Liver carboxylesterase 1; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Belongs to the type-B carboxylesterase/lipase family.	Arylamine N-acetyltransferase 1; Belongs to the arylamine N-acetyltransferase family.	0.902
G1TPR2_RABIT	HGSNAT	ENSOCUP00000018999	ENSOCUP00000006996	Glucosamine 6-phosphate N-acetyltransferase.	Heparan-alpha-glucosaminide N-acetyltransferase.	0.457
G1TPR2_RABIT	NAT1	ENSOCUP00000018999	ENSOCUP00000024297	Glucosamine 6-phosphate N-acetyltransferase.	Arylamine N-acetyltransferase 1; Belongs to the arylamine N-acetyltransferase family.	0.531
GNPNAT1	HGSNAT	ENSOCUP00000006793	ENSOCUP00000006996	Glucosamine 6-phosphate N-acetyltransferase.	Heparan-alpha-glucosaminide N-acetyltransferase.	0.437
GNPNAT1	NAT1	ENSOCUP00000006793	ENSOCUP00000024297	Glucosamine 6-phosphate N-acetyltransferase.	Arylamine N-acetyltransferase 1; Belongs to the arylamine N-acetyltransferase family.	0.524
HGSNAT	G1TPR2_RABIT	ENSOCUP00000006996	ENSOCUP00000018999	Heparan-alpha-glucosaminide N-acetyltransferase.	Glucosamine 6-phosphate N-acetyltransferase.	0.457