node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALDH1A2 | CYP26A1 | ENSOCUP00000014561 | ENSOCUP00000000158 | Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. | Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. | 0.975 |
ALDH1A2 | FDX1 | ENSOCUP00000014561 | ENSOCUP00000046511 | Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. | 2Fe-2S ferredoxin-type domain-containing protein. | 0.482 |
ALDH1A2 | KMO | ENSOCUP00000014561 | ENSOCUP00000006661 | Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. | 0.430 |
ALDH1A2 | RDH14 | ENSOCUP00000014561 | ENSOCUP00000024512 | Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. | Retinol dehydrogenase 14; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.526 |
ALDH1A2 | STRA6 | ENSOCUP00000014561 | ENSOCUP00000020771 | Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. | Stimulated by retinoic acid 6. | 0.531 |
CHST15 | ERMARD | ENSOCUP00000026648 | ENSOCUP00000005980 | Carbohydrate sulfotransferase 15. | ER membrane associated RNA degradation. | 0.495 |
CHST15 | RDH14 | ENSOCUP00000026648 | ENSOCUP00000024512 | Carbohydrate sulfotransferase 15. | Retinol dehydrogenase 14; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.509 |
CYP26A1 | ALDH1A2 | ENSOCUP00000000158 | ENSOCUP00000014561 | Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. | Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. | 0.975 |
CYP26A1 | FDX1 | ENSOCUP00000000158 | ENSOCUP00000046511 | Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. | 2Fe-2S ferredoxin-type domain-containing protein. | 0.477 |
CYP26A1 | RBP2 | ENSOCUP00000000158 | ENSOCUP00000038129 | Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. | Retinol binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. | 0.537 |
CYP26A1 | RDH14 | ENSOCUP00000000158 | ENSOCUP00000024512 | Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. | Retinol dehydrogenase 14; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.499 |
CYP26A1 | STRA6 | ENSOCUP00000000158 | ENSOCUP00000020771 | Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. | Stimulated by retinoic acid 6. | 0.738 |
ERMARD | CHST15 | ENSOCUP00000005980 | ENSOCUP00000026648 | ER membrane associated RNA degradation. | Carbohydrate sulfotransferase 15. | 0.495 |
ERMARD | RDH14 | ENSOCUP00000005980 | ENSOCUP00000024512 | ER membrane associated RNA degradation. | Retinol dehydrogenase 14; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.496 |
FDX1 | ALDH1A2 | ENSOCUP00000046511 | ENSOCUP00000014561 | 2Fe-2S ferredoxin-type domain-containing protein. | Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. | 0.482 |
FDX1 | CYP26A1 | ENSOCUP00000046511 | ENSOCUP00000000158 | 2Fe-2S ferredoxin-type domain-containing protein. | Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. | 0.477 |
FDX1 | KMO | ENSOCUP00000046511 | ENSOCUP00000006661 | 2Fe-2S ferredoxin-type domain-containing protein. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. | 0.771 |
FDX1 | RDH14 | ENSOCUP00000046511 | ENSOCUP00000024512 | 2Fe-2S ferredoxin-type domain-containing protein. | Retinol dehydrogenase 14; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.534 |
KMO | ALDH1A2 | ENSOCUP00000006661 | ENSOCUP00000014561 | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. | Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. | 0.430 |
KMO | FDX1 | ENSOCUP00000006661 | ENSOCUP00000046511 | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. | 2Fe-2S ferredoxin-type domain-containing protein. | 0.771 |