| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACE | ACE2 | ENSOCUP00000022251 | ENSOCUP00000015275 | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | Angiotensin-converting enzyme. | 0.523 |
| ACE | AGT | ENSOCUP00000022251 | ENSOCUP00000000417 | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | Angiotensinogen; Belongs to the serpin family. | 0.979 |
| ACE | AGTR1 | ENSOCUP00000022251 | ENSOCUP00000028622 | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | 0.929 |
| ACE | AGTR2 | ENSOCUP00000022251 | ENSOCUP00000010638 | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | Angiotensin receptor 2; Belongs to the G-protein coupled receptor 1 family. | 0.805 |
| ACE | REN | ENSOCUP00000022251 | ENSOCUP00000017597 | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | Renin; Belongs to the peptidase A1 family. | 0.981 |
| ACE2 | ACE | ENSOCUP00000015275 | ENSOCUP00000022251 | Angiotensin-converting enzyme. | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | 0.523 |
| ACE2 | AGT | ENSOCUP00000015275 | ENSOCUP00000000417 | Angiotensin-converting enzyme. | Angiotensinogen; Belongs to the serpin family. | 0.985 |
| ACE2 | AGTR1 | ENSOCUP00000015275 | ENSOCUP00000028622 | Angiotensin-converting enzyme. | Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | 0.967 |
| ACE2 | AGTR2 | ENSOCUP00000015275 | ENSOCUP00000010638 | Angiotensin-converting enzyme. | Angiotensin receptor 2; Belongs to the G-protein coupled receptor 1 family. | 0.827 |
| ACE2 | LOC103351595 | ENSOCUP00000015275 | ENSOCUP00000037472 | Angiotensin-converting enzyme. | Angiotensin-converting enzyme. | 0.490 |
| ACE2 | REN | ENSOCUP00000015275 | ENSOCUP00000017597 | Angiotensin-converting enzyme. | Renin; Belongs to the peptidase A1 family. | 0.981 |
| AGT | ACE | ENSOCUP00000000417 | ENSOCUP00000022251 | Angiotensinogen; Belongs to the serpin family. | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | 0.979 |
| AGT | ACE2 | ENSOCUP00000000417 | ENSOCUP00000015275 | Angiotensinogen; Belongs to the serpin family. | Angiotensin-converting enzyme. | 0.985 |
| AGT | AGTR1 | ENSOCUP00000000417 | ENSOCUP00000028622 | Angiotensinogen; Belongs to the serpin family. | Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | 0.999 |
| AGT | AGTR2 | ENSOCUP00000000417 | ENSOCUP00000010638 | Angiotensinogen; Belongs to the serpin family. | Angiotensin receptor 2; Belongs to the G-protein coupled receptor 1 family. | 0.999 |
| AGT | GNA14 | ENSOCUP00000000417 | ENSOCUP00000004776 | Angiotensinogen; Belongs to the serpin family. | G protein subunit alpha 14. | 0.543 |
| AGT | GNAQ | ENSOCUP00000000417 | ENSOCUP00000014234 | Angiotensinogen; Belongs to the serpin family. | G protein subunit alpha q. | 0.540 |
| AGT | LOC103351595 | ENSOCUP00000000417 | ENSOCUP00000037472 | Angiotensinogen; Belongs to the serpin family. | Angiotensin-converting enzyme. | 0.979 |
| AGT | REN | ENSOCUP00000000417 | ENSOCUP00000017597 | Angiotensinogen; Belongs to the serpin family. | Renin; Belongs to the peptidase A1 family. | 0.945 |
| AGTR1 | ACE | ENSOCUP00000028622 | ENSOCUP00000022251 | Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | 0.929 |