node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CGA | FSHR | ENSOCUP00000007243 | ENSOCUP00000009670 | Glycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. | Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. | 0.993 |
CGA | LHB | ENSOCUP00000007243 | ENSOCUP00000025405 | Glycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. | Lutropin subunit beta; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. | 0.996 |
CGA | LHCGR | ENSOCUP00000007243 | ENSOCUP00000027034 | Glycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. | Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. | 0.975 |
CGA | POMC | ENSOCUP00000007243 | ENSOCUP00000037970 | Glycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. | NPP domain-containing protein. | 0.626 |
ENSOCUP00000025080 | LHB | ENSOCUP00000025080 | ENSOCUP00000025405 | annotation not available | Lutropin subunit beta; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. | 0.648 |
ENSOCUP00000034492 | LHB | ENSOCUP00000034492 | ENSOCUP00000025405 | NTF2 domain-containing protein. | Lutropin subunit beta; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. | 0.648 |
FANCA | LHB | ENSOCUP00000015531 | ENSOCUP00000025405 | FA complementation group A. | Lutropin subunit beta; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. | 0.648 |
FOS | LHB | ENSOCUP00000021434 | ENSOCUP00000025405 | Fos proto-oncogene, AP-1 transcription factor subunit. | Lutropin subunit beta; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. | 0.729 |
FOS | POMC | ENSOCUP00000021434 | ENSOCUP00000037970 | Fos proto-oncogene, AP-1 transcription factor subunit. | NPP domain-containing protein. | 0.654 |
FSHR | CGA | ENSOCUP00000009670 | ENSOCUP00000007243 | Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. | Glycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. | 0.993 |
FSHR | LHB | ENSOCUP00000009670 | ENSOCUP00000025405 | Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. | Lutropin subunit beta; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. | 0.711 |
FSHR | POMC | ENSOCUP00000009670 | ENSOCUP00000037970 | Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. | NPP domain-containing protein. | 0.912 |
LHB | CGA | ENSOCUP00000025405 | ENSOCUP00000007243 | Lutropin subunit beta; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. | Glycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. | 0.996 |
LHB | ENSOCUP00000025080 | ENSOCUP00000025405 | ENSOCUP00000025080 | Lutropin subunit beta; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. | annotation not available | 0.648 |
LHB | ENSOCUP00000034492 | ENSOCUP00000025405 | ENSOCUP00000034492 | Lutropin subunit beta; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. | NTF2 domain-containing protein. | 0.648 |
LHB | FANCA | ENSOCUP00000025405 | ENSOCUP00000015531 | Lutropin subunit beta; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. | FA complementation group A. | 0.648 |
LHB | FOS | ENSOCUP00000025405 | ENSOCUP00000021434 | Lutropin subunit beta; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. | Fos proto-oncogene, AP-1 transcription factor subunit. | 0.729 |
LHB | FSHR | ENSOCUP00000025405 | ENSOCUP00000009670 | Lutropin subunit beta; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. | Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. | 0.711 |
LHB | LHCGR | ENSOCUP00000025405 | ENSOCUP00000027034 | Lutropin subunit beta; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. | Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. | 0.976 |
LHB | NUTF2 | ENSOCUP00000025405 | ENSOCUP00000005465 | Lutropin subunit beta; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. | NTF2 domain-containing protein. | 0.648 |