node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HDAC1 | HDAC2 | ENSOCUP00000037903 | ENSOCUP00000040151 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | Histone deacetylase 2. | 0.998 |
HDAC1 | KDM1A | ENSOCUP00000037903 | ENSOCUP00000001013 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.988 |
HDAC1 | KDM1B | ENSOCUP00000037903 | ENSOCUP00000003349 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | Lysine demethylase 1B. | 0.626 |
HDAC1 | MAOA | ENSOCUP00000037903 | ENSOCUP00000001233 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | Amine oxidase. | 0.570 |
HDAC1 | MAOB | ENSOCUP00000037903 | ENSOCUP00000036753 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | Amine oxidase. | 0.611 |
HDAC1 | MECP2 | ENSOCUP00000037903 | ENSOCUP00000048554 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). | 0.988 |
HDAC1 | PHF21A | ENSOCUP00000037903 | ENSOCUP00000001434 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | PHD finger protein 21A. | 0.808 |
HDAC1 | RCOR2 | ENSOCUP00000037903 | ENSOCUP00000025542 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | REST corepressor 2. | 0.791 |
HDAC1 | REST | ENSOCUP00000037903 | ENSOCUP00000001526 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | RE1 silencing transcription factor. | 0.970 |
HDAC1 | ZNF217 | ENSOCUP00000037903 | ENSOCUP00000009778 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | Zinc finger protein 217. | 0.812 |
HDAC2 | HDAC1 | ENSOCUP00000040151 | ENSOCUP00000037903 | Histone deacetylase 2. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | 0.998 |
HDAC2 | KDM1A | ENSOCUP00000040151 | ENSOCUP00000001013 | Histone deacetylase 2. | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.985 |
HDAC2 | KDM1B | ENSOCUP00000040151 | ENSOCUP00000003349 | Histone deacetylase 2. | Lysine demethylase 1B. | 0.574 |
HDAC2 | MAOA | ENSOCUP00000040151 | ENSOCUP00000001233 | Histone deacetylase 2. | Amine oxidase. | 0.572 |
HDAC2 | MAOB | ENSOCUP00000040151 | ENSOCUP00000036753 | Histone deacetylase 2. | Amine oxidase. | 0.604 |
HDAC2 | MECP2 | ENSOCUP00000040151 | ENSOCUP00000048554 | Histone deacetylase 2. | Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). | 0.980 |
HDAC2 | PHF21A | ENSOCUP00000040151 | ENSOCUP00000001434 | Histone deacetylase 2. | PHD finger protein 21A. | 0.871 |
HDAC2 | RCOR2 | ENSOCUP00000040151 | ENSOCUP00000025542 | Histone deacetylase 2. | REST corepressor 2. | 0.852 |
HDAC2 | REST | ENSOCUP00000040151 | ENSOCUP00000001526 | Histone deacetylase 2. | RE1 silencing transcription factor. | 0.703 |
HDAC2 | ZNF217 | ENSOCUP00000040151 | ENSOCUP00000009778 | Histone deacetylase 2. | Zinc finger protein 217. | 0.852 |