Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CDC42-2Uncharacterized protein. (222 aa)    
Predicted Functional Partners:
WAS
WASP actin nucleation promoting factor.
   
 0.991
PAK1
Non-specific serine/threonine protein kinase.
   
 0.990
PAK2
Serine/threonine-protein kinase PAK 2; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream targ [...]
   
 0.986
IQGAP1
IQ motif containing GTPase activating protein 1.
   
 0.986
WASL
WASP like actin nucleation promoting factor.
   
 0.985
VAV1
Vav guanine nucleotide exchange factor 1.
   
 0.978
IQGAP2
IQ motif containing GTPase activating protein 2.
   
 0.977
IQGAP3
IQ motif containing GTPase activating protein 3.
   
 0.971
PARD6B
Par-6 family cell polarity regulator beta.
    
 0.970
PARD6A
Par-6 family cell polarity regulator alpha.
    
 0.966
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.