STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDC42-2Uncharacterized protein. (222 aa)    
Predicted Functional Partners:
WAS
WASP actin nucleation promoting factor.
   
 0.999
IQGAP1
IQ motif containing GTPase activating protein 1.
   
 0.999
PAK1
Non-specific serine/threonine protein kinase.
   
 0.999
WASL
WASP like actin nucleation promoting factor.
   
 0.997
PARD6B
Par-6 family cell polarity regulator beta.
    
 0.997
ITSN2
Intersectin 2.
    
 0.997
PAK2
Serine/threonine-protein kinase PAK 2; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream targ [...]
   
 0.995
PAK6
Non-specific serine/threonine protein kinase.
   
 0.995
PAK4
P21 (RAC1) activated kinase 4.
   
 0.993
PARD6A
Par-6 family cell polarity regulator alpha.
    
 0.992
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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