EIF4A2 protein (Oryctolagus cuniculus) - STRING interaction network

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EIF4A2

Uncharacterized protein; Belongs to the DEAD box helicase family. (413 aa)

Predicted Functional Partners:

EIF4G3

0.916

EIF4A1

0.882

U3KMP9_RABIT

0.882

ENSOCUP00000035909

0.882

ENSOCUP00000046701

0.882

EIF4B

0.869

EIF4G1

0.860

EIF4E

0.852

PDCD4

0.843

EIF4G2

0.834

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EIF4A1	EIF4A2	ENSOCUP00000008940	ENSOCUP00000028436	Eukaryotic initiation factor 4A-I; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.	Uncharacterized protein; Belongs to the DEAD box helicase family.	0.882
EIF4A1	EIF4B	ENSOCUP00000008940	ENSOCUP00000011602	Eukaryotic initiation factor 4A-I; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.	Eukaryotic translation initiation factor 4B.	0.986
EIF4A1	EIF4E	ENSOCUP00000008940	ENSOCUP00000032078	Eukaryotic initiation factor 4A-I; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.	Eukaryotic translation initiation factor 4E; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap (By similarity).	0.987
EIF4A1	EIF4G1	ENSOCUP00000008940	ENSOCUP00000032992	Eukaryotic initiation factor 4A-I; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.	Eukaryotic translation initiation factor 4 gamma 1; Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.	0.994
EIF4A1	EIF4G2	ENSOCUP00000008940	ENSOCUP00000046928	Eukaryotic initiation factor 4A-I; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.	Eukaryotic translation initiation factor 4 gamma 2; Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. Belongs to the eukaryotic initiation factor 4G family.	0.954
EIF4A1	EIF4G3	ENSOCUP00000008940	ENSOCUP00000048212	Eukaryotic initiation factor 4A-I; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.	Eukaryotic translation initiation factor 4 gamma 3.	0.952
EIF4A1	PDCD4	ENSOCUP00000008940	ENSOCUP00000030567	Eukaryotic initiation factor 4A-I; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.	Programmed cell death 4.	0.917
EIF4A2	EIF4A1	ENSOCUP00000028436	ENSOCUP00000008940	Uncharacterized protein; Belongs to the DEAD box helicase family.	Eukaryotic initiation factor 4A-I; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.	0.882
EIF4A2	EIF4B	ENSOCUP00000028436	ENSOCUP00000011602	Uncharacterized protein; Belongs to the DEAD box helicase family.	Eukaryotic translation initiation factor 4B.	0.869
EIF4A2	EIF4E	ENSOCUP00000028436	ENSOCUP00000032078	Uncharacterized protein; Belongs to the DEAD box helicase family.	Eukaryotic translation initiation factor 4E; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap (By similarity).	0.852
EIF4A2	EIF4G1	ENSOCUP00000028436	ENSOCUP00000032992	Uncharacterized protein; Belongs to the DEAD box helicase family.	Eukaryotic translation initiation factor 4 gamma 1; Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.	0.860
EIF4A2	EIF4G2	ENSOCUP00000028436	ENSOCUP00000046928	Uncharacterized protein; Belongs to the DEAD box helicase family.	Eukaryotic translation initiation factor 4 gamma 2; Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. Belongs to the eukaryotic initiation factor 4G family.	0.834
EIF4A2	EIF4G3	ENSOCUP00000028436	ENSOCUP00000048212	Uncharacterized protein; Belongs to the DEAD box helicase family.	Eukaryotic translation initiation factor 4 gamma 3.	0.916
EIF4A2	ENSOCUP00000035909	ENSOCUP00000028436	ENSOCUP00000035909	Uncharacterized protein; Belongs to the DEAD box helicase family.	Uncharacterized protein; Belongs to the DEAD box helicase family.	0.882
EIF4A2	ENSOCUP00000046701	ENSOCUP00000028436	ENSOCUP00000046701	Uncharacterized protein; Belongs to the DEAD box helicase family.	Uncharacterized protein; Belongs to the DEAD box helicase family.	0.882
EIF4A2	PDCD4	ENSOCUP00000028436	ENSOCUP00000030567	Uncharacterized protein; Belongs to the DEAD box helicase family.	Programmed cell death 4.	0.843
EIF4A2	U3KMP9_RABIT	ENSOCUP00000028436	ENSOCUP00000026508	Uncharacterized protein; Belongs to the DEAD box helicase family.	Uncharacterized protein; Belongs to the DEAD box helicase family.	0.882
EIF4B	EIF4A1	ENSOCUP00000011602	ENSOCUP00000008940	Eukaryotic translation initiation factor 4B.	Eukaryotic initiation factor 4A-I; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.	0.986
EIF4B	EIF4A2	ENSOCUP00000011602	ENSOCUP00000028436	Eukaryotic translation initiation factor 4B.	Uncharacterized protein; Belongs to the DEAD box helicase family.	0.869
EIF4B	EIF4E	ENSOCUP00000011602	ENSOCUP00000032078	Eukaryotic translation initiation factor 4B.	Eukaryotic translation initiation factor 4E; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap (By similarity).	0.968