STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)    
Predicted Functional Partners:
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.998
RIPK1
Receptor interacting serine/threonine kinase 1.
   
 0.997
TNFRSF1A
TNF receptor superfamily member 1A.
    
 0.985
SPATA2
Spermatogenesis associated 2.
     
 0.972
SQSTM1
Sequestosome 1.
   
 0.971
CASP8
DED domain-containing protein.
   
 0.963
DDX58
DExD/H-box helicase 58.
    
 0.958
G1TXZ4_RABIT
Uncharacterized protein.
   
 0.947
TRADD
TNFRSF1A associated via death domain.
   
 
 0.944
UBB
Ubiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11- [...]
   
 0.904
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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