node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C1QA | C1S | ENSOCUP00000026373 | ENSOCUP00000012442 | Complement C1q A chain. | Complement C1s; Belongs to the peptidase S1 family. | 0.841 |
C1QA | C3 | ENSOCUP00000026373 | ENSOCUP00000006634 | Complement C1q A chain. | Complement C3 alpha chain; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. | 0.498 |
C1QA | C4A | ENSOCUP00000026373 | ENSOCUP00000006093 | Complement C1q A chain. | Uncharacterized protein. | 0.689 |
C1QA | C5AR1 | ENSOCUP00000026373 | ENSOCUP00000023879 | Complement C1q A chain. | C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N- terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (By similarity). | 0.737 |
C1QA | C5AR2 | ENSOCUP00000026373 | ENSOCUP00000034050 | Complement C1q A chain. | Complement component 5a receptor 2. | 0.432 |
C1QA | IL1B | ENSOCUP00000026373 | ENSOCUP00000021869 | Complement C1q A chain. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.479 |
C1QA | LOC100346672 | ENSOCUP00000026373 | ENSOCUP00000008700 | Complement C1q A chain. | Uncharacterized protein. | 0.498 |
C1S | C1QA | ENSOCUP00000012442 | ENSOCUP00000026373 | Complement C1s; Belongs to the peptidase S1 family. | Complement C1q A chain. | 0.841 |
C1S | C3 | ENSOCUP00000012442 | ENSOCUP00000006634 | Complement C1s; Belongs to the peptidase S1 family. | Complement C3 alpha chain; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. | 0.768 |
C1S | C4A | ENSOCUP00000012442 | ENSOCUP00000006093 | Complement C1s; Belongs to the peptidase S1 family. | Uncharacterized protein. | 0.990 |
C1S | C5 | ENSOCUP00000012442 | ENSOCUP00000004927 | Complement C1s; Belongs to the peptidase S1 family. | Complement C5. | 0.413 |
C1S | C5AR1 | ENSOCUP00000012442 | ENSOCUP00000023879 | Complement C1s; Belongs to the peptidase S1 family. | C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N- terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (By similarity). | 0.587 |
C1S | C5AR2 | ENSOCUP00000012442 | ENSOCUP00000034050 | Complement C1s; Belongs to the peptidase S1 family. | Complement component 5a receptor 2. | 0.545 |
C1S | LOC100346672 | ENSOCUP00000012442 | ENSOCUP00000008700 | Complement C1s; Belongs to the peptidase S1 family. | Uncharacterized protein. | 0.768 |
C3 | C1QA | ENSOCUP00000006634 | ENSOCUP00000026373 | Complement C3 alpha chain; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. | Complement C1q A chain. | 0.498 |
C3 | C1S | ENSOCUP00000006634 | ENSOCUP00000012442 | Complement C3 alpha chain; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. | Complement C1s; Belongs to the peptidase S1 family. | 0.768 |
C3 | C5 | ENSOCUP00000006634 | ENSOCUP00000004927 | Complement C3 alpha chain; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. | Complement C5. | 0.579 |
C3 | C5AR1 | ENSOCUP00000006634 | ENSOCUP00000023879 | Complement C3 alpha chain; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. | C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N- terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (By similarity). | 0.702 |
C3 | C5AR2 | ENSOCUP00000006634 | ENSOCUP00000034050 | Complement C3 alpha chain; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. | Complement component 5a receptor 2. | 0.536 |
C3 | ENSOCUP00000027220 | ENSOCUP00000006634 | ENSOCUP00000027220 | Complement C3 alpha chain; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. | Anaphylatoxin-like domain-containing protein. | 0.509 |