node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KRAS | KSR1 | ENSOCUP00000010411 | ENSOCUP00000006098 | KRAS proto-oncogene, GTPase. | Kinase suppressor of ras 1. | 0.646 |
KRAS | MAP2K1 | ENSOCUP00000010411 | ENSOCUP00000029057 | KRAS proto-oncogene, GTPase. | Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] | 0.989 |
KRAS | NRAS | ENSOCUP00000010411 | ENSOCUP00000019559 | KRAS proto-oncogene, GTPase. | NRAS proto-oncogene, GTPase. | 0.902 |
KRAS | RAF1 | ENSOCUP00000010411 | ENSOCUP00000036596 | KRAS proto-oncogene, GTPase. | Raf-1 proto-oncogene, serine/threonine kinase. | 0.981 |
KRAS | YWHAB | ENSOCUP00000010411 | ENSOCUP00000034985 | KRAS proto-oncogene, GTPase. | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. | 0.417 |
KRAS | YWHAZ | ENSOCUP00000010411 | ENSOCUP00000000636 | KRAS proto-oncogene, GTPase. | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. | 0.422 |
KSR1 | KRAS | ENSOCUP00000006098 | ENSOCUP00000010411 | Kinase suppressor of ras 1. | KRAS proto-oncogene, GTPase. | 0.646 |
KSR1 | MAP2K1 | ENSOCUP00000006098 | ENSOCUP00000029057 | Kinase suppressor of ras 1. | Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] | 0.993 |
KSR1 | NRAS | ENSOCUP00000006098 | ENSOCUP00000019559 | Kinase suppressor of ras 1. | NRAS proto-oncogene, GTPase. | 0.585 |
KSR1 | RAF1 | ENSOCUP00000006098 | ENSOCUP00000036596 | Kinase suppressor of ras 1. | Raf-1 proto-oncogene, serine/threonine kinase. | 0.968 |
KSR1 | RAP1A | ENSOCUP00000006098 | ENSOCUP00000041165 | Kinase suppressor of ras 1. | Uncharacterized protein. | 0.624 |
KSR1 | RAP1B | ENSOCUP00000006098 | ENSOCUP00000041229 | Kinase suppressor of ras 1. | Uncharacterized protein. | 0.613 |
KSR1 | YWHAB | ENSOCUP00000006098 | ENSOCUP00000034985 | Kinase suppressor of ras 1. | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. | 0.683 |
KSR1 | YWHAH | ENSOCUP00000006098 | ENSOCUP00000034630 | Kinase suppressor of ras 1. | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. | 0.565 |
KSR1 | YWHAQ | ENSOCUP00000006098 | ENSOCUP00000009032 | Kinase suppressor of ras 1. | 14-3-3 protein theta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity). | 0.572 |
KSR1 | YWHAZ | ENSOCUP00000006098 | ENSOCUP00000000636 | Kinase suppressor of ras 1. | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. | 0.572 |
MAP2K1 | KRAS | ENSOCUP00000029057 | ENSOCUP00000010411 | Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] | KRAS proto-oncogene, GTPase. | 0.989 |
MAP2K1 | KSR1 | ENSOCUP00000029057 | ENSOCUP00000006098 | Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] | Kinase suppressor of ras 1. | 0.993 |
MAP2K1 | NRAS | ENSOCUP00000029057 | ENSOCUP00000019559 | Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] | NRAS proto-oncogene, GTPase. | 0.991 |
MAP2K1 | RAF1 | ENSOCUP00000029057 | ENSOCUP00000036596 | Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] | Raf-1 proto-oncogene, serine/threonine kinase. | 0.991 |