node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGT | AGTR1 | ENSOCUP00000000417 | ENSOCUP00000028622 | Angiotensinogen; Belongs to the serpin family. | Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | 0.999 |
AGT | CLTRN | ENSOCUP00000000417 | ENSOCUP00000011254 | Angiotensinogen; Belongs to the serpin family. | Collectrin domain-containing protein. | 0.750 |
AGT | CMA1 | ENSOCUP00000000417 | ENSOCUP00000020875 | Angiotensinogen; Belongs to the serpin family. | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. | 0.868 |
AGT | EDN1 | ENSOCUP00000000417 | ENSOCUP00000011526 | Angiotensinogen; Belongs to the serpin family. | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | 0.808 |
AGT | G1TFB0_RABIT | ENSOCUP00000000417 | ENSOCUP00000015600 | Angiotensinogen; Belongs to the serpin family. | Peptidase S1 domain-containing protein. | 0.579 |
AGT | KNG1 | ENSOCUP00000000417 | ENSOCUP00000033073 | Angiotensinogen; Belongs to the serpin family. | Kininogen 1. | 0.772 |
AGT | LOC103351595 | ENSOCUP00000000417 | ENSOCUP00000037472 | Angiotensinogen; Belongs to the serpin family. | Angiotensin-converting enzyme. | 0.979 |
AGT | MME | ENSOCUP00000000417 | ENSOCUP00000041310 | Angiotensinogen; Belongs to the serpin family. | Neprilysin; Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers. Belongs to the peptidase M13 family. | 0.862 |
AGT | NR3C2 | ENSOCUP00000000417 | ENSOCUP00000002724 | Angiotensinogen; Belongs to the serpin family. | Nuclear receptor subfamily 3 group C member 2. | 0.689 |
AGT | REN | ENSOCUP00000000417 | ENSOCUP00000017597 | Angiotensinogen; Belongs to the serpin family. | Renin; Belongs to the peptidase A1 family. | 0.945 |
AGTR1 | AGT | ENSOCUP00000028622 | ENSOCUP00000000417 | Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | Angiotensinogen; Belongs to the serpin family. | 0.999 |
AGTR1 | CMA1 | ENSOCUP00000028622 | ENSOCUP00000020875 | Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. | 0.594 |
AGTR1 | EDN1 | ENSOCUP00000028622 | ENSOCUP00000011526 | Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | 0.850 |
AGTR1 | G1TFB0_RABIT | ENSOCUP00000028622 | ENSOCUP00000015600 | Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | Peptidase S1 domain-containing protein. | 0.544 |
AGTR1 | KNG1 | ENSOCUP00000028622 | ENSOCUP00000033073 | Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | Kininogen 1. | 0.709 |
AGTR1 | LOC103351595 | ENSOCUP00000028622 | ENSOCUP00000037472 | Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | Angiotensin-converting enzyme. | 0.929 |
AGTR1 | MME | ENSOCUP00000028622 | ENSOCUP00000041310 | Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | Neprilysin; Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers. Belongs to the peptidase M13 family. | 0.470 |
AGTR1 | NR3C2 | ENSOCUP00000028622 | ENSOCUP00000002724 | Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | Nuclear receptor subfamily 3 group C member 2. | 0.592 |
AGTR1 | REN | ENSOCUP00000028622 | ENSOCUP00000017597 | Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. | Renin; Belongs to the peptidase A1 family. | 0.869 |
CLTRN | AGT | ENSOCUP00000011254 | ENSOCUP00000000417 | Collectrin domain-containing protein. | Angiotensinogen; Belongs to the serpin family. | 0.750 |