PTK2-2 protein (Oryctolagus cuniculus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

PTK2-2

FERM_N_2 domain-containing protein. (121 aa)

Predicted Functional Partners:

GRB2

0.995

EGFR

0.991

BCAR1

0.990

DCC

0.983

ITGB1

0.979

FYN

0.976

JAK2

0.966

PTEN

0.965

CRKL

0.963

PIK3R1

0.963

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCAR1	CRKL	ENSOCUP00000037429	ENSOCUP00000000710	BCAR1 scaffold protein, Cas family member.	CRK like proto-oncogene, adaptor protein.	0.990
BCAR1	EGFR	ENSOCUP00000037429	ENSOCUP00000009041	BCAR1 scaffold protein, Cas family member.	Receptor protein-tyrosine kinase.	0.465
BCAR1	FYN	ENSOCUP00000037429	ENSOCUP00000013559	BCAR1 scaffold protein, Cas family member.	Tyrosine-protein kinase.	0.932
BCAR1	GRB2	ENSOCUP00000037429	ENSOCUP00000042433	BCAR1 scaffold protein, Cas family member.	Growth factor receptor bound protein 2.	0.774
BCAR1	ITGB1	ENSOCUP00000037429	ENSOCUP00000003143	BCAR1 scaffold protein, Cas family member.	Integrin beta; Belongs to the integrin beta chain family.	0.862
BCAR1	PTK2-2	ENSOCUP00000037429	ENSOCUP00000038411	BCAR1 scaffold protein, Cas family member.	FERM_N_2 domain-containing protein.	0.990
CRKL	BCAR1	ENSOCUP00000000710	ENSOCUP00000037429	CRK like proto-oncogene, adaptor protein.	BCAR1 scaffold protein, Cas family member.	0.990
CRKL	EGFR	ENSOCUP00000000710	ENSOCUP00000009041	CRK like proto-oncogene, adaptor protein.	Receptor protein-tyrosine kinase.	0.980
CRKL	FYN	ENSOCUP00000000710	ENSOCUP00000013559	CRK like proto-oncogene, adaptor protein.	Tyrosine-protein kinase.	0.757
CRKL	GRB2	ENSOCUP00000000710	ENSOCUP00000042433	CRK like proto-oncogene, adaptor protein.	Growth factor receptor bound protein 2.	0.937
CRKL	ITGB1	ENSOCUP00000000710	ENSOCUP00000003143	CRK like proto-oncogene, adaptor protein.	Integrin beta; Belongs to the integrin beta chain family.	0.828
CRKL	JAK2	ENSOCUP00000000710	ENSOCUP00000014491	CRK like proto-oncogene, adaptor protein.	Tyrosine-protein kinase.	0.644
CRKL	PIK3R1	ENSOCUP00000000710	ENSOCUP00000004433	CRK like proto-oncogene, adaptor protein.	Phosphoinositide-3-kinase regulatory subunit 1.	0.969
CRKL	PTK2-2	ENSOCUP00000000710	ENSOCUP00000038411	CRK like proto-oncogene, adaptor protein.	FERM_N_2 domain-containing protein.	0.963
DCC	FYN	ENSOCUP00000042388	ENSOCUP00000013559	DCC netrin 1 receptor.	Tyrosine-protein kinase.	0.468
DCC	PTK2-2	ENSOCUP00000042388	ENSOCUP00000038411	DCC netrin 1 receptor.	FERM_N_2 domain-containing protein.	0.983
EGFR	BCAR1	ENSOCUP00000009041	ENSOCUP00000037429	Receptor protein-tyrosine kinase.	BCAR1 scaffold protein, Cas family member.	0.465
EGFR	CRKL	ENSOCUP00000009041	ENSOCUP00000000710	Receptor protein-tyrosine kinase.	CRK like proto-oncogene, adaptor protein.	0.980
EGFR	FYN	ENSOCUP00000009041	ENSOCUP00000013559	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.784
EGFR	GRB2	ENSOCUP00000009041	ENSOCUP00000042433	Receptor protein-tyrosine kinase.	Growth factor receptor bound protein 2.	0.999