STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NUB1Negative regulator of ubiquitin like proteins 1. (646 aa)    
Predicted Functional Partners:
NEDD8
NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity).
    
 0.943
PSMD4
Proteasome 26S subunit, non-ATPase, 4 (Predicted).
   
 0.908
PSMD5
Proteasome 26S subunit, non-ATPase 5.
     
 0.872
UBD
Ubiquitin D.
    
 0.800
PSME2
Proteasome activator subunit 2.
   
 
 0.790
AIPL1
Aryl hydrocarbon receptor interacting protein like 1.
    
 
 0.730
HERC6
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6.
      
 0.679
PSMC3
Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family.
     
 0.630
PSMD3
Proteasome 26S subunit, non-ATPase 3.
     
 0.629
SENP8
SUMO peptidase family member, NEDD8 specific.
     
 0.627
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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