node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AIPL1 | NEDD8 | ENSOCUP00000021015 | ENSOCUP00000002526 | Aryl hydrocarbon receptor interacting protein like 1. | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). | 0.619 |
AIPL1 | NUB1 | ENSOCUP00000021015 | ENSOCUP00000039029 | Aryl hydrocarbon receptor interacting protein like 1. | Negative regulator of ubiquitin like proteins 1. | 0.730 |
HERC6 | NUB1 | ENSOCUP00000026560 | ENSOCUP00000039029 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6. | Negative regulator of ubiquitin like proteins 1. | 0.679 |
HERC6 | PSMD4 | ENSOCUP00000026560 | ENSOCUP00000004455 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6. | Proteasome 26S subunit, non-ATPase, 4 (Predicted). | 0.466 |
HERC6 | PSME2 | ENSOCUP00000026560 | ENSOCUP00000002480 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6. | Proteasome activator subunit 2. | 0.431 |
HERC6 | UBD | ENSOCUP00000026560 | ENSOCUP00000025788 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6. | Ubiquitin D. | 0.428 |
NEDD8 | AIPL1 | ENSOCUP00000002526 | ENSOCUP00000021015 | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). | Aryl hydrocarbon receptor interacting protein like 1. | 0.619 |
NEDD8 | NUB1 | ENSOCUP00000002526 | ENSOCUP00000039029 | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). | Negative regulator of ubiquitin like proteins 1. | 0.943 |
NEDD8 | PSMC3 | ENSOCUP00000002526 | ENSOCUP00000017910 | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). | Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. | 0.789 |
NEDD8 | PSMD3 | ENSOCUP00000002526 | ENSOCUP00000028084 | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). | Proteasome 26S subunit, non-ATPase 3. | 0.746 |
NEDD8 | PSMD4 | ENSOCUP00000002526 | ENSOCUP00000004455 | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). | Proteasome 26S subunit, non-ATPase, 4 (Predicted). | 0.868 |
NEDD8 | PSMD5 | ENSOCUP00000002526 | ENSOCUP00000004895 | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). | Proteasome 26S subunit, non-ATPase 5. | 0.727 |
NEDD8 | PSME2 | ENSOCUP00000002526 | ENSOCUP00000002480 | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). | Proteasome activator subunit 2. | 0.577 |
NEDD8 | SENP8 | ENSOCUP00000002526 | ENSOCUP00000021911 | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). | SUMO peptidase family member, NEDD8 specific. | 0.999 |
NEDD8 | UBD | ENSOCUP00000002526 | ENSOCUP00000025788 | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). | Ubiquitin D. | 0.701 |
NUB1 | AIPL1 | ENSOCUP00000039029 | ENSOCUP00000021015 | Negative regulator of ubiquitin like proteins 1. | Aryl hydrocarbon receptor interacting protein like 1. | 0.730 |
NUB1 | HERC6 | ENSOCUP00000039029 | ENSOCUP00000026560 | Negative regulator of ubiquitin like proteins 1. | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6. | 0.679 |
NUB1 | NEDD8 | ENSOCUP00000039029 | ENSOCUP00000002526 | Negative regulator of ubiquitin like proteins 1. | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). | 0.943 |
NUB1 | PSMC3 | ENSOCUP00000039029 | ENSOCUP00000017910 | Negative regulator of ubiquitin like proteins 1. | Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. | 0.630 |
NUB1 | PSMD3 | ENSOCUP00000039029 | ENSOCUP00000028084 | Negative regulator of ubiquitin like proteins 1. | Proteasome 26S subunit, non-ATPase 3. | 0.629 |