SPIRE1 protein (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SPIRE1

Spire type actin nucleation factor 1. (821 aa)

Predicted Functional Partners:

FMN2

0.944

GRAP2

0.837

FMN1

0.835

MYO5B

0.802

GRB2

0.763

NCK1

0.626

NCK2

0.626

VAV1

0.607

VAV3

0.607

PLCG2

0.594

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FMN1	FMN2	ENSOCUP00000004861	ENSOCUP00000023697	Formin 1.	Formin 2.	0.509
FMN1	SPIRE1	ENSOCUP00000004861	ENSOCUP00000039416	Formin 1.	Spire type actin nucleation factor 1.	0.835
FMN2	FMN1	ENSOCUP00000023697	ENSOCUP00000004861	Formin 2.	Formin 1.	0.509
FMN2	MYO5B	ENSOCUP00000023697	ENSOCUP00000022397	Formin 2.	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.768
FMN2	SPIRE1	ENSOCUP00000023697	ENSOCUP00000039416	Formin 2.	Spire type actin nucleation factor 1.	0.944
GRAP2	GRB2	ENSOCUP00000010557	ENSOCUP00000042433	GRB2 related adaptor protein 2.	Growth factor receptor bound protein 2.	0.848
GRAP2	NCK1	ENSOCUP00000010557	ENSOCUP00000006673	GRB2 related adaptor protein 2.	Cytoplasmic protein.	0.754
GRAP2	NCK2	ENSOCUP00000010557	ENSOCUP00000023883	GRB2 related adaptor protein 2.	Cytoplasmic protein.	0.581
GRAP2	PLCG2	ENSOCUP00000010557	ENSOCUP00000011293	GRB2 related adaptor protein 2.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.847
GRAP2	SPIRE1	ENSOCUP00000010557	ENSOCUP00000039416	GRB2 related adaptor protein 2.	Spire type actin nucleation factor 1.	0.837
GRAP2	VAV1	ENSOCUP00000010557	ENSOCUP00000022704	GRB2 related adaptor protein 2.	Vav guanine nucleotide exchange factor 1.	0.880
GRAP2	VAV3	ENSOCUP00000010557	ENSOCUP00000036367	GRB2 related adaptor protein 2.	Vav guanine nucleotide exchange factor 3.	0.663
GRB2	GRAP2	ENSOCUP00000042433	ENSOCUP00000010557	Growth factor receptor bound protein 2.	GRB2 related adaptor protein 2.	0.848
GRB2	NCK1	ENSOCUP00000042433	ENSOCUP00000006673	Growth factor receptor bound protein 2.	Cytoplasmic protein.	0.852
GRB2	NCK2	ENSOCUP00000042433	ENSOCUP00000023883	Growth factor receptor bound protein 2.	Cytoplasmic protein.	0.801
GRB2	PLCG2	ENSOCUP00000042433	ENSOCUP00000011293	Growth factor receptor bound protein 2.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.886
GRB2	SPIRE1	ENSOCUP00000042433	ENSOCUP00000039416	Growth factor receptor bound protein 2.	Spire type actin nucleation factor 1.	0.763
GRB2	VAV1	ENSOCUP00000042433	ENSOCUP00000022704	Growth factor receptor bound protein 2.	Vav guanine nucleotide exchange factor 1.	0.997
GRB2	VAV3	ENSOCUP00000042433	ENSOCUP00000036367	Growth factor receptor bound protein 2.	Vav guanine nucleotide exchange factor 3.	0.896
MYO5B	FMN2	ENSOCUP00000022397	ENSOCUP00000023697	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	Formin 2.	0.768