DYNAP protein (Oryctolagus cuniculus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Score

DYNAP

CLLAC domain-containing protein. (202 aa)

Predicted Functional Partners:

G1U1Y5_RABIT

0.694

FAU

0.694

ENSOCUP00000046875

0.694

ENSOCUP00000049185

0.694

G1TZC2_RABIT

0.519

ENSOCUP00000032071

0.519

GLE1

0.491

RPS15

0.467

RPS28

0.461

ASF1A

0.429

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASF1A	DYNAP	ENSOCUP00000023179	ENSOCUP00000040219	Uncharacterized protein.	CLLAC domain-containing protein.	0.429
DYNAP	ASF1A	ENSOCUP00000040219	ENSOCUP00000023179	CLLAC domain-containing protein.	Uncharacterized protein.	0.429
DYNAP	ENSOCUP00000032071	ENSOCUP00000040219	ENSOCUP00000032071	CLLAC domain-containing protein.	RanBD1 domain-containing protein.	0.519
DYNAP	ENSOCUP00000046875	ENSOCUP00000040219	ENSOCUP00000046875	CLLAC domain-containing protein.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.694
DYNAP	ENSOCUP00000049185	ENSOCUP00000040219	ENSOCUP00000049185	CLLAC domain-containing protein.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.694
DYNAP	FAU	ENSOCUP00000040219	ENSOCUP00000042864	CLLAC domain-containing protein.	Ubiquitin-like domain-containing protein.	0.694
DYNAP	G1TZC2_RABIT	ENSOCUP00000040219	ENSOCUP00000022444	CLLAC domain-containing protein.	Uncharacterized protein.	0.519
DYNAP	G1U1Y5_RABIT	ENSOCUP00000040219	ENSOCUP00000023377	CLLAC domain-containing protein.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.694
DYNAP	GLE1	ENSOCUP00000040219	ENSOCUP00000010609	CLLAC domain-containing protein.	GLE1 RNA export mediator.	0.491
DYNAP	RPS15	ENSOCUP00000040219	ENSOCUP00000022933	CLLAC domain-containing protein.	Ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	0.467
DYNAP	RPS28	ENSOCUP00000040219	ENSOCUP00000016683	CLLAC domain-containing protein.	Ribosomal protein S28.	0.461
ENSOCUP00000032071	DYNAP	ENSOCUP00000032071	ENSOCUP00000040219	RanBD1 domain-containing protein.	CLLAC domain-containing protein.	0.519
ENSOCUP00000032071	GLE1	ENSOCUP00000032071	ENSOCUP00000010609	RanBD1 domain-containing protein.	GLE1 RNA export mediator.	0.962
ENSOCUP00000046875	DYNAP	ENSOCUP00000046875	ENSOCUP00000040219	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	CLLAC domain-containing protein.	0.694
ENSOCUP00000046875	ENSOCUP00000049185	ENSOCUP00000046875	ENSOCUP00000049185	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.912
ENSOCUP00000046875	FAU	ENSOCUP00000046875	ENSOCUP00000042864	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	Ubiquitin-like domain-containing protein.	0.914
ENSOCUP00000046875	G1U1Y5_RABIT	ENSOCUP00000046875	ENSOCUP00000023377	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.912
ENSOCUP00000046875	RPS15	ENSOCUP00000046875	ENSOCUP00000022933	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	Ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	0.999
ENSOCUP00000046875	RPS28	ENSOCUP00000046875	ENSOCUP00000016683	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	Ribosomal protein S28.	0.999
ENSOCUP00000049185	DYNAP	ENSOCUP00000049185	ENSOCUP00000040219	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	CLLAC domain-containing protein.	0.694

page 1 of 3

Network Stats

number of nodes:

10

number of edges:

39

average node degree:

7.8

avg. local clustering coefficient:

0.95

expected number of edges:

10

PPI enrichment p-value:

2.96e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006644

Phospholipid metabolic process

5 of 350

1.42

1.15

0.0016

GO:0019637

Organophosphate metabolic process

7 of 816

1.2

1.1

0.00043

GO:0016042

Lipid catabolic process

4 of 245

1.47

0.99

0.0063

GO:0006629

Lipid metabolic process

7 of 1093

1.07

0.87

0.0016

GO:0044255

Cellular lipid metabolic process

6 of 848

1.11

0.86

0.0030

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004623

Phospholipase A2 activity

4 of 40

2.26

2.59

8.53e-06

GO:0016788

Hydrolase activity, acting on ester bonds

8 of 813

1.25

1.54

2.90e-06

GO:0004528

Phosphodiesterase I activity

2 of 5

2.86

1.5

0.0019

GO:0004551

Nucleotide diphosphatase activity

2 of 15

2.39

1.09

0.0097

GO:0008081

Phosphoric diester hydrolase activity

3 of 103

1.73

1.07

0.0066

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:25342

Linoleic acid metabolism, and Glycerophospholipid catabolism

10 of 53

2.54

9.65

1.99e-21

CL:25343

Linoleic acid metabolism, and 1-alkyl-2-acetylglycerophosphocholine esterase complex

8 of 44

2.52

7.59

1.96e-16

CL:25345

Linoleic acid metabolism, and Synthesis of 15-eicosatetraenoic acid derivatives

6 of 33

2.52

5.48

1.37e-11

CL:25396

Phosphodiesterase I activity, and N-acylethanolamine metabolic process

3 of 5

3.04

2.92

4.78e-06

CL:25349

Mixed, incl. Icosanoid secretion, and Lipoxygenase

2 of 18

2.31

0.82

0.0309

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00565

Ether lipid metabolism

11 of 95

2.33

9.46

9.95e-24

map00592

alpha-Linolenic acid metabolism

6 of 43

2.41

5.45

6.77e-12

map00591

Linoleic acid metabolism

6 of 46

2.38

5.4

6.77e-12

map00590

Arachidonic acid metabolism

6 of 94

2.07

4.23

2.28e-10

map00564

Glycerophospholipid metabolism

7 of 207

1.79

3.57

2.17e-10

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1482788

Acyl chain remodelling of PC

4 of 42

2.24

2.5

1.29e-05

MAP-1483206

Glycerophospholipid biosynthesis

5 of 201

1.66

1.92

2.60e-05

MAP-1483257

Phospholipid metabolism

6 of 338

1.51

1.83

1.29e-05

MAP-1482839

Acyl chain remodelling of PE

3 of 43

2.11

1.61

0.00075

MAP-196843

Vitamin B2 (riboflavin) metabolism

2 of 12

2.48

1.22

0.0058

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01663

Type I phosphodiesterase / nucleotide pyrophosphatase

3 of 12

2.66

2.13

0.00012

PF06951

Group XII secretory phospholipase A2 precursor (PLA2G12)

2 of 3

3.09

1.4

0.0030

PF04970

Lecithin retinol acyltransferase

2 of 12

2.48

0.95

0.0181

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00201

Somatomedin B -like domains

2 of 8

2.66

1.13

0.0090

SM00477

DNA/RNA non-specific endonuclease

2 of 14

2.42

1.05

0.0120

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