CLUAP1 protein (Oryctolagus cuniculus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

CLUAP1

Clusterin associated protein 1. (400 aa)

Predicted Functional Partners:

IFT80

0.998

IFT57

0.998

IFT88

0.997

IFT52

0.996

IFT81

0.996

TRAF3IP1

0.995

TTC26

0.994

IFT172

0.993

IFT74

0.982

IFT22

0.980

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLUAP1	IFT172	ENSOCUP00000040517	ENSOCUP00000003749	Clusterin associated protein 1.	Intraflagellar transport 172.	0.993
CLUAP1	IFT22	ENSOCUP00000040517	ENSOCUP00000032675	Clusterin associated protein 1.	Intraflagellar transport 22.	0.980
CLUAP1	IFT52	ENSOCUP00000040517	ENSOCUP00000005773	Clusterin associated protein 1.	Intraflagellar transport 52.	0.996
CLUAP1	IFT57	ENSOCUP00000040517	ENSOCUP00000040399	Clusterin associated protein 1.	Intraflagellar transport 57.	0.998
CLUAP1	IFT74	ENSOCUP00000040517	ENSOCUP00000001139	Clusterin associated protein 1.	Intraflagellar transport 74.	0.982
CLUAP1	IFT80	ENSOCUP00000040517	ENSOCUP00000012749	Clusterin associated protein 1.	Intraflagellar transport 80.	0.998
CLUAP1	IFT81	ENSOCUP00000040517	ENSOCUP00000008448	Clusterin associated protein 1.	Intraflagellar transport 81.	0.996
CLUAP1	IFT88	ENSOCUP00000040517	ENSOCUP00000042332	Clusterin associated protein 1.	Intraflagellar transport 88.	0.997
CLUAP1	TRAF3IP1	ENSOCUP00000040517	ENSOCUP00000001322	Clusterin associated protein 1.	Uncharacterized protein.	0.995
CLUAP1	TTC26	ENSOCUP00000040517	ENSOCUP00000015379	Clusterin associated protein 1.	Tetratricopeptide repeat domain 26.	0.994
IFT172	CLUAP1	ENSOCUP00000003749	ENSOCUP00000040517	Intraflagellar transport 172.	Clusterin associated protein 1.	0.993
IFT172	IFT22	ENSOCUP00000003749	ENSOCUP00000032675	Intraflagellar transport 172.	Intraflagellar transport 22.	0.989
IFT172	IFT52	ENSOCUP00000003749	ENSOCUP00000005773	Intraflagellar transport 172.	Intraflagellar transport 52.	0.998
IFT172	IFT57	ENSOCUP00000003749	ENSOCUP00000040399	Intraflagellar transport 172.	Intraflagellar transport 57.	0.999
IFT172	IFT74	ENSOCUP00000003749	ENSOCUP00000001139	Intraflagellar transport 172.	Intraflagellar transport 74.	0.994
IFT172	IFT80	ENSOCUP00000003749	ENSOCUP00000012749	Intraflagellar transport 172.	Intraflagellar transport 80.	0.999
IFT172	IFT81	ENSOCUP00000003749	ENSOCUP00000008448	Intraflagellar transport 172.	Intraflagellar transport 81.	0.999
IFT172	IFT88	ENSOCUP00000003749	ENSOCUP00000042332	Intraflagellar transport 172.	Intraflagellar transport 88.	0.999
IFT172	TRAF3IP1	ENSOCUP00000003749	ENSOCUP00000001322	Intraflagellar transport 172.	Uncharacterized protein.	0.993
IFT172	TTC26	ENSOCUP00000003749	ENSOCUP00000015379	Intraflagellar transport 172.	Tetratricopeptide repeat domain 26.	0.995

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

15

average node degree:

2.73

avg. local clustering coefficient:

0.859

expected number of edges:

10

PPI enrichment p-value:

0.105

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032957

Inositol trisphosphate metabolic process

4 of 5

3.24

4.19

2.40e-08

GO:0070266

Necroptotic process

4 of 13

2.83

3.59

2.27e-07

GO:0006066

Alcohol metabolic process

5 of 291

1.58

1.61

0.00014

GO:0052746

Inositol phosphorylation

2 of 3

3.16

1.54

0.0017

GO:0032958

Inositol phosphate biosynthetic process

2 of 14

2.5

0.97

0.0167

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000825

Inositol tetrakisphosphate 6-kinase activity

4 of 4

3.34

4.61

4.39e-09

GO:0051766

Inositol trisphosphate kinase activity

4 of 9

2.99

4.26

1.49e-08

GO:0003993

Acid phosphatase activity

3 of 7

2.97

2.88

5.66e-06

GO:0102732

myo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase activity

2 of 2

3.34

1.83

0.00051

GO:0052726

inositol-1,3,4-trisphosphate 5-kinase activity

2 of 2

3.34

1.83

0.00051

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:30075

Acid phosphatase activity, and Alkaline phosphatase activity

6 of 14

2.97

6.68

3.23e-13

CL:30076

Acid phosphatase activity, and Phosphodiesterase I activity

4 of 7

3.1

4.32

1.27e-08

CL:38050

Inositol trisphosphate kinase activity, and Inositol tetrakisphosphate phosphatase activity

4 of 17

2.71

3.62

1.72e-07

CL:38074

Inositol phosphorylation, and Inositol tetrakisphosphate 5-kinase activity

3 of 5

3.12

2.98

3.89e-06

CL:30089

Alkaline phosphatase activity, and Acid phosphatase activity

2 of 7

2.8

1.41

0.0028

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00730

Thiamine metabolism

4 of 21

2.62

3.84

5.24e-08

map00740

Riboflavin metabolism

3 of 19

2.54

2.8

5.30e-06

map00562

Inositol phosphate metabolism

5 of 169

1.81

2.66

5.39e-07

map04070

Phosphatidylinositol signaling system

4 of 181

1.68

1.89

4.16e-05

map01100

Metabolic pathways

11 of 3242

0.87

0.96

5.24e-08

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1483249

Inositol phosphate metabolism

5 of 70

2.19

3.28

1.94e-07

MAP-196819

Vitamin B1 (thiamin) metabolism

2 of 5

2.94

1.47

0.0022

MAP-1855191

Synthesis of IPs in the nucleus

2 of 7

2.8

1.41

0.0028

MAP-1855167

Synthesis of pyrophosphates in the cytosol

2 of 10

2.64

1.3

0.0042

MAP-196849

Metabolism of water-soluble vitamins and cofactors

3 of 192

1.53

0.79

0.0228

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00149

Calcineurin-like phosphoesterase

3 of 14

2.67

2.15

0.00011

PF05770

Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain

2 of 2

3.34

1.6

0.0013

PF03770

Inositol polyphosphate kinase

2 of 9

2.69

1.15

0.0081

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