| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APP | BACE1 | ENSOCUP00000009130 | ENSOCUP00000025190 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Beta-secretase 1; Belongs to the peptidase A1 family. | 0.997 |
| APP | BCHE | ENSOCUP00000009130 | ENSOCUP00000042058 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Cholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters (By similarity). | 0.926 |
| APP | NGF | ENSOCUP00000009130 | ENSOCUP00000021708 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Nerve growth factor. | 0.699 |
| BACE1 | APP | ENSOCUP00000025190 | ENSOCUP00000009130 | Beta-secretase 1; Belongs to the peptidase A1 family. | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.997 |
| BACE1 | BCHE | ENSOCUP00000025190 | ENSOCUP00000042058 | Beta-secretase 1; Belongs to the peptidase A1 family. | Cholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters (By similarity). | 0.737 |
| BACE1 | NGF | ENSOCUP00000025190 | ENSOCUP00000021708 | Beta-secretase 1; Belongs to the peptidase A1 family. | Nerve growth factor. | 0.422 |
| BCHE | APP | ENSOCUP00000042058 | ENSOCUP00000009130 | Cholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters (By similarity). | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.926 |
| BCHE | BACE1 | ENSOCUP00000042058 | ENSOCUP00000025190 | Cholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters (By similarity). | Beta-secretase 1; Belongs to the peptidase A1 family. | 0.737 |
| BCHE | CHAT | ENSOCUP00000042058 | ENSOCUP00000016652 | Cholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters (By similarity). | Choline O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. | 0.918 |
| BCHE | COLQ | ENSOCUP00000042058 | ENSOCUP00000013844 | Cholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters (By similarity). | Collagen like tail subunit of asymmetric acetylcholinesterase. | 0.809 |
| BCHE | GHRL | ENSOCUP00000042058 | ENSOCUP00000029787 | Cholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters (By similarity). | Uncharacterized protein. | 0.824 |
| BCHE | GOT1 | ENSOCUP00000042058 | ENSOCUP00000033978 | Cholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters (By similarity). | Aspartate aminotransferase. | 0.677 |
| BCHE | GPCPD1 | ENSOCUP00000042058 | ENSOCUP00000017295 | Cholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters (By similarity). | Glycerophosphocholine phosphodiesterase 1. | 0.865 |
| BCHE | NGF | ENSOCUP00000042058 | ENSOCUP00000021708 | Cholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters (By similarity). | Nerve growth factor. | 0.696 |
| BCHE | PHOSPHO1 | ENSOCUP00000042058 | ENSOCUP00000014050 | Cholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters (By similarity). | Phosphoethanolamine/phosphocholine phosphatase. | 0.845 |
| BCHE | PON1 | ENSOCUP00000042058 | ENSOCUP00000046112 | Cholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters (By similarity). | Serum paraoxonase/arylesterase 1; Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification. Belongs to the paraoxonase family. | 0.690 |
| CHAT | BCHE | ENSOCUP00000016652 | ENSOCUP00000042058 | Choline O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. | Cholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters (By similarity). | 0.918 |
| CHAT | GPCPD1 | ENSOCUP00000016652 | ENSOCUP00000017295 | Choline O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. | Glycerophosphocholine phosphodiesterase 1. | 0.890 |
| CHAT | NGF | ENSOCUP00000016652 | ENSOCUP00000021708 | Choline O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. | Nerve growth factor. | 0.460 |
| CHAT | PHOSPHO1 | ENSOCUP00000016652 | ENSOCUP00000014050 | Choline O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. | Phosphoethanolamine/phosphocholine phosphatase. | 0.866 |
