| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARRB1 | EGFR | ENSOCUP00000019641 | ENSOCUP00000009041 | Beta-arrestin-1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...] | Receptor protein-tyrosine kinase. | 0.843 |
| ARRB1 | FYN | ENSOCUP00000019641 | ENSOCUP00000013559 | Beta-arrestin-1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...] | Tyrosine-protein kinase. | 0.402 |
| ARRB1 | SRC | ENSOCUP00000019641 | ENSOCUP00000043750 | Beta-arrestin-1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...] | Tyrosine-protein kinase. | 0.933 |
| BCAR1 | CTTN | ENSOCUP00000037429 | ENSOCUP00000031724 | BCAR1 scaffold protein, Cas family member. | Cortactin. | 0.481 |
| BCAR1 | EGFR | ENSOCUP00000037429 | ENSOCUP00000009041 | BCAR1 scaffold protein, Cas family member. | Receptor protein-tyrosine kinase. | 0.461 |
| BCAR1 | ESR1 | ENSOCUP00000037429 | ENSOCUP00000004174 | BCAR1 scaffold protein, Cas family member. | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.689 |
| BCAR1 | FYN | ENSOCUP00000037429 | ENSOCUP00000013559 | BCAR1 scaffold protein, Cas family member. | Tyrosine-protein kinase. | 0.985 |
| BCAR1 | HCLS1 | ENSOCUP00000037429 | ENSOCUP00000010712 | BCAR1 scaffold protein, Cas family member. | Hematopoietic cell-specific Lyn substrate 1. | 0.414 |
| BCAR1 | PXN | ENSOCUP00000037429 | ENSOCUP00000034749 | BCAR1 scaffold protein, Cas family member. | Paxillin. | 0.953 |
| BCAR1 | SRC | ENSOCUP00000037429 | ENSOCUP00000043750 | BCAR1 scaffold protein, Cas family member. | Tyrosine-protein kinase. | 0.941 |
| CAV1 | CTTN | ENSOCUP00000012485 | ENSOCUP00000031724 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] | Cortactin. | 0.610 |
| CAV1 | EGFR | ENSOCUP00000012485 | ENSOCUP00000009041 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] | Receptor protein-tyrosine kinase. | 0.995 |
| CAV1 | ESR1 | ENSOCUP00000012485 | ENSOCUP00000004174 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.944 |
| CAV1 | FYN | ENSOCUP00000012485 | ENSOCUP00000013559 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] | Tyrosine-protein kinase. | 0.971 |
| CAV1 | HCLS1 | ENSOCUP00000012485 | ENSOCUP00000010712 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] | Hematopoietic cell-specific Lyn substrate 1. | 0.575 |
| CAV1 | PXN | ENSOCUP00000012485 | ENSOCUP00000034749 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] | Paxillin. | 0.668 |
| CAV1 | SRC | ENSOCUP00000012485 | ENSOCUP00000043750 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] | Tyrosine-protein kinase. | 0.959 |
| CAV1 | STAT3 | ENSOCUP00000012485 | ENSOCUP00000009494 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] | Signal transducer and activator of transcription. | 0.547 |
| CTTN | BCAR1 | ENSOCUP00000031724 | ENSOCUP00000037429 | Cortactin. | BCAR1 scaffold protein, Cas family member. | 0.481 |
| CTTN | CAV1 | ENSOCUP00000031724 | ENSOCUP00000012485 | Cortactin. | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] | 0.610 |
